Human liver cancer organoids: Biological applications, current challenges, and prospects in hepatoma therapy

L Chen, X Wei, D Gu, Y Xu, H Zhou - Cancer Letters, 2023 - Elsevier
Liver cancer and disease are among the most socially challenging global health concerns.
Although organ transplantation, surgical resection and anticancer drugs are the main …

Vaccine-associated enhanced respiratory pathology in COVID-19 hamsters after TH2-biased immunization

A Ebenig, S Muraleedharan, J Kazmierski, D Todt… - Cell reports, 2022 - cell.com
Vaccine-associated enhanced respiratory disease (VAERD) is a severe complication for
some respiratory infections. To investigate the potential for VAERD induction in coronavirus …

Cost of universality: A comparative study of the overhead of state distillation and code switching with color codes

ME Beverland, A Kubica, KM Svore - PRX Quantum, 2021 - APS
Estimating and reducing the overhead of fault-tolerance (FT) schemes is a crucial step
toward realizing scalable quantum computers. Of particular interest are schemes based on …

The diverse roles of peroxisomes in the interplay between viruses and mammalian cells

H Jiang, V Nair, Y Sun, C Ding - Antiviral Research, 2024 - Elsevier
Peroxisomes are ubiquitous organelles found in eukaryotic cells that play a critical role in
the oxidative metabolism of lipids and detoxification of reactive oxygen species (ROS) …

TMPRSS2-mediated SARS-CoV-2 uptake boosts innate immune activation, enhances cytopathology, and drives convergent virus evolution

B Qu, C Miskey, A Gömer, RDV Kleinert… - Proceedings of the …, 2024 - pnas.org
The accessory protease transmembrane protease serine 2 (TMPRSS2) enhances severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2) uptake into ACE2-expressing …

Targeting cellular cathepsins inhibits hepatitis E virus entry

M Klöhn, T Burkard, J Janzen, JA Haase, A Gömer… - Hepatology, 2024 - journals.lww.com
Conclusions: In summary, our study highlights the pivotal role of lysosomal cathepsins,
especially CTSL, in the HEV entry process. The profound anti-HEV efficacy of the pan …

Universal fault-tolerant measurement-based quantum computation

BJ Brown, S Roberts - Physical Review Research, 2020 - APS
Certain physical systems that one might consider for fault-tolerant quantum computing
where qubits do not readily interact, for instance photons, are better suited for measurement …

MicroRNAs modulate SARS‐CoV‐2 infection of primary human hepatocytes by regulating the entry factors ACE2 and TMPRSS2

R Khanal, N Heinen, A Bogomolova… - Liver …, 2024 - Wiley Online Library
Abstract Background and Aims Severe acute respiratory syndrome coronavirus (SARS‐CoV‐
2) preferentially infects the respiratory tract; however, several studies have implicated a multi …

Implementation of a controlled human infection model for evaluation of HCV vaccine candidates

E Barnes, GS Cooke, GM Lauer, RT Chung - Hepatology, 2023 - journals.lww.com
Hepatitis C virus (HCV) remains a major global health concern. Directly acting antiviral
(DAA) drugs have transformed the treatment of HCV. However, it has become clear that …

A C-type lectin-like receptor CD302 in yellow drum (Nibea albiflora) functioning in antibacterial activity and innate immune signaling

J Peng, J Li, J Liang, W Li, Y Yang, Y Yang… - International Journal of …, 2023 - Elsevier
Molecular dissection of disease resistance against Vibrio harveyi infection in yellow drum at
the genome-wide level uncovered a C-type lectin-like receptor cluster of differentiation …