The role of extracellular vesicles in cancer
Intercellular communication is a key feature of cancer progression and metastasis.
Extracellular vesicles (EVs) are generated by all cells, including cancer cells, and recent …
Extracellular vesicles (EVs) are generated by all cells, including cancer cells, and recent …
Liquid biopsy: a step closer to transform diagnosis, prognosis and future of cancer treatments
Over the past decade, invasive techniques for diagnosing and monitoring cancers are slowly
being replaced by non-invasive methods such as liquid biopsy. Liquid biopsies have …
being replaced by non-invasive methods such as liquid biopsy. Liquid biopsies have …
Targeting non-coding RNAs to overcome cancer therapy resistance
BQ Chen, MP Dragomir, C Yang, Q Li, D Horst… - Signal transduction and …, 2022 - nature.com
It is now well known that non-coding RNAs (ncRNAs), rather than protein-coding transcripts,
are the preponderant RNA transcripts. NcRNAs, particularly microRNAs (miRNAs), long non …
are the preponderant RNA transcripts. NcRNAs, particularly microRNAs (miRNAs), long non …
Long noncoding RNAs in cancer metastasis
Metastasis is a major contributor to cancer-associated deaths. It is characterized by a
multistep process that occurs through the acquisition of molecular and phenotypic changes …
multistep process that occurs through the acquisition of molecular and phenotypic changes …
EWSR1-induced circNEIL3 promotes glioma progression and exosome-mediated macrophage immunosuppressive polarization via stabilizing IGF2BP3
Z Pan, R Zhao, B Li, Y Qi, W Qiu, Q Guo, S Zhang… - Molecular cancer, 2022 - Springer
Background Gliomas are the most common malignant primary brain tumours with a highly
immunosuppressive tumour microenvironment (TME) and poor prognosis. Circular RNAs …
immunosuppressive tumour microenvironment (TME) and poor prognosis. Circular RNAs …
Application of exosomes as liquid biopsy in clinical diagnosis
B Zhou, K Xu, X Zheng, T Chen, J Wang… - Signal transduction and …, 2020 - nature.com
Liquid biopsy refers to the sampling and molecular analysis of the biofluids of circulating
tumor cells, extracellular vesicles, nucleic acids, and so forth. Exosomes are small …
tumor cells, extracellular vesicles, nucleic acids, and so forth. Exosomes are small …
Extracellular vesicles in kidney disease
C Grange, B Bussolati - Nature Reviews Nephrology, 2022 - nature.com
Extracellular vesicles are released by the majority of cell types and circulate in body fluids.
They function as a long-distance cell-to-cell communication mechanism that modulates the …
They function as a long-distance cell-to-cell communication mechanism that modulates the …
Shedding light on extracellular vesicle biogenesis and bioengineering
F Teng, M Fussenegger - Advanced Science, 2021 - Wiley Online Library
Extracellular vesicles (EVs) are biocompatible, nano‐sized secreted vesicles containing
many types of biomolecules, including proteins, RNAs, DNAs, lipids, and metabolites. Their …
many types of biomolecules, including proteins, RNAs, DNAs, lipids, and metabolites. Their …
CircRNA-SORE mediates sorafenib resistance in hepatocellular carcinoma by stabilizing YBX1
Sorafenib is the first-line chemotherapeutic therapy for advanced hepatocellular carcinoma
(HCC). However, sorafenib resistance significantly limits its therapeutic efficacy, and the …
(HCC). However, sorafenib resistance significantly limits its therapeutic efficacy, and the …
Exosomal circRNA: emerging insights into cancer progression and clinical application potential
F Zhang, J Jiang, H Qian, Y Yan, W Xu - Journal of Hematology & …, 2023 - Springer
Exosomal circRNA serves a novel genetic information molecule, facilitating communication
between tumor cells and microenvironmental cells, such as immune cells, fibroblasts, and …
between tumor cells and microenvironmental cells, such as immune cells, fibroblasts, and …