Cancer is a complex disease involving numerous biological processes, which can exist in
parallel, can be complementary, or are engaged when needed and as such can replace …

At least 468 individual genes have been manipulated by molecular methods to study their
effects on the initiation, promotion, and progression of atherosclerosis. Most clinicians and …

Major depression and anxiety disorders have high prevalence rates and are frequently
comorbid. The neurobiological bases for these disorders are not fully understood, and …

Ceramides are a class of sphingolipids that are abundant in cell membranes. They are
important structural components of the membrane but can also act as second messengers in …

The thioredoxin (Trx) system comprises Trx, truncated Trx (Trx-80), Trx reductase, and
NADPH, besides a natural Trx inhibitor, the thioredoxin-interacting protein (TXNIP). This …

Psychiatric disorders like mood disorders, schizophrenia, or drug addiction affect a sizeable
proportion of the human population and severely compromise quality of life. Therefore …

Acid sphingomyelinase (ASM) is an important lipid-metabolizing enzyme cleaving
sphingomyelin to ceramide, mainly within lysosomes. Acid ceramidase (AC) further …

Chronic obstructive pulmonary diseases (COPD), comprised of pulmonary emphysema,
chronic bronchitis, and structural and inflammatory changes of small airways, is a leading …

Cellular stress elicited by the toxic metal Cd 2+ does not coerce the cell into committing to
die from the onset. Rather, detoxification and adaptive processes are triggered concurrently …

Background: Ceramides exhibit multiple biological activities that may influence the
pathophysiology of heart failure. These activities may be influenced by the saturated fatty …