Lysine acetylation is a widespread and versatile protein post-translational modification.
Lysine acetyltransferases and lysine deacetylases catalyse the addition or removal …

Precise spatio–temporal control of gene activity is essential for organismal development,
growth, and survival in a changing environment. Decisive steps in gene regulation involve …

Pathogenic and other cytoplasmic DNAs activate the cyclic GMP-AMP synthase (cGAS)-
stimulator of interferon genes (STING) pathway to induce inflammation via transcriptional …

In response to stress, human cells coordinately downregulate transcription and translation of
housekee** genes. To downregulate transcription, the negative elongation factor (NELF) …

For cells to initiate and sustain a differentiated state, it is necessary that a 'memory'of this
state is transmitted through mitosis to the daughter cells,–. Mammalian switch/sucrose non …

The Cyclin-dependent kinase 1, as a serine/threonine protein kinase, is more than a cell
cycle regulator as it was originally identified. During the last decade, it has been shown to …

Gene expression programs change over time, differentiation and development, and in
response to stimuli. However, nearly all techniques for profiling gene expression in single …

During self-renewal, cell-type-defining features are drastically perturbed in mitosis and must
be faithfully reestablished upon G1 entry, a process that remains largely elusive. Here, we …

Mitotic catastrophe (MC), which occurs under dysregulated mitosis, represents a fascinating
tactic to specifically eradicate tumor cells. Whether pyroptosis can be a death form of MC …

Transcription-coupled supercoiling of DNA is a key factor in chromosome compaction and
the regulation of genetic processes in all domains of life. It has become common knowledge …