Understanding disease progression and improving Alzheimer's disease clinical trials: Recent highlights from the Alzheimer's Disease Neuroimaging Initiative
DP Veitch, MW Weiner, PS Aisen, LA Beckett… - Alzheimer's & …, 2019 - Elsevier
Introduction The overall goal of the Alzheimer's Disease Neuroimaging Initiative (ADNI) is to
validate biomarkers for Alzheimer's disease (AD) clinical trials. ADNI is a multisite …
validate biomarkers for Alzheimer's disease (AD) clinical trials. ADNI is a multisite …
Cerebral small vessel disease: neuroimaging markers and clinical implication
X Chen, J Wang, Y Shan, W Cai, S Liu, M Hu, S Liao… - Journal of …, 2019 - Springer
Cerebral small vessel disease (CSVD) is a broad category of cerebrovascular diseases
which primarily affect the perforating arterioles, capillaries and venules with multiple distinct …
which primarily affect the perforating arterioles, capillaries and venules with multiple distinct …
Parietal white matter lesions in Alzheimer's disease are associated with cortical neurodegenerative pathology, but not with small vessel disease
Cerebral white matter lesions (WML) encompass axonal loss and demyelination, and the
pathogenesis is assumed to be small vessel disease (SVD)-related ischemia. However …
pathogenesis is assumed to be small vessel disease (SVD)-related ischemia. However …
Frontal white matter lesions in Alzheimer's disease are associated with both small vessel disease and AD-associated cortical pathology
KE McAleese, M Miah, S Graham, GM Hadfield… - Acta …, 2021 - Springer
Cerebral white matter lesions (WML) encompass axonal loss and demyelination and are
assumed to be associated with small vessel disease (SVD)-related ischaemia. However, our …
assumed to be associated with small vessel disease (SVD)-related ischaemia. However, our …
White matter hyperintensities and CSF Alzheimer disease biomarkers in preclinical Alzheimer disease
Objective Recent studies suggest that white matter hyperintensities (WMH) on MRI, which
primarily reflect small vessel cerebrovascular disease, may play a role in the evolution of …
primarily reflect small vessel cerebrovascular disease, may play a role in the evolution of …
White matter hyperintensities and their relationship to cognition: Effects of segmentation algorithm
White matter hyperintensities (WMHs) are brain white matter lesions that are hyperintense
on fluid attenuated inversion recovery (FLAIR) magnetic resonance imaging (MRI) scans …
on fluid attenuated inversion recovery (FLAIR) magnetic resonance imaging (MRI) scans …
Neuropathologic correlates of white matter hyperintensities in a community-based cohort of older adults
Background: The association of white matter hyperintensities (WMH) with age-related
vascular and neurodegenerative pathologies remains incompletely understood. Objective …
vascular and neurodegenerative pathologies remains incompletely understood. Objective …
White matter hypointensities and hyperintensities have equivalent correlations with age and CSF β‐amyloid in the nondemented elderly
Abstract Introduction T1‐and T2‐weighted sequences from MRI often provide useful
complementary information about tissue properties. Leukoaraiosis results in signal …
complementary information about tissue properties. Leukoaraiosis results in signal …
[HTML][HTML] Cerebral amyloid burden is associated with white matter hyperintensity location in specific posterior white matter regions
White matter hyperintensities (WMHs) are a common manifestation of cerebral small vessel
disease. WMHs are also frequently observed in patients with familial and sporadic …
disease. WMHs are also frequently observed in patients with familial and sporadic …
White matter hyperintensities are associated with subthreshold amyloid accumulation
The association between white matter hyperintensities (WMH) and amyloid accumulation
over time in cognitively normal, amyloid-negative elderly people remains largely …
over time in cognitively normal, amyloid-negative elderly people remains largely …