[HTML][HTML] Microbial production of polyunsaturated fatty acids—high-value ingredients for aquafeed, superfoods, and pharmaceuticals

S Jovanovic, D Dietrich, J Becker, M Kohlstedt… - Current opinion in …, 2021 - Elsevier
Highlights•PUFAs are applied worldwide in superfoods, aquafeed and pharmaceuticals.•
Climate warming and declining fishery cause a severe supply and demand gap.•The PUFAs …

Production of polyunsaturated fatty acids by Schizochytrium (Aurantiochytrium) spp.

G Chi, Y Xu, X Cao, Z Li, M Cao, Y Chisti, N He - Biotechnology advances, 2022 - Elsevier
Diverse health benefits are associated with dietary consumption of omega-3 long-chain
polyunsaturated fatty acids (ω-3 LC-PUFA), particularly docosahexaenoic acid (DHA) and …

Stresses as first-line tools for enhancing lipid and carotenoid production in microalgae

TQ Shi, LR Wang, ZX Zhang, XM Sun… - … in bioengineering and …, 2020 - frontiersin.org
Microalgae can produce high-value-added products such as lipids and carotenoids using
light or sugars, and their biosynthesis mechanism can be triggered by various stress …

Thraustochytrids as production organisms for docosahexaenoic acid (DHA), squalene, and carotenoids

IM Aasen, H Ertesvåg, TMB Heggeset, B Liu… - Applied microbiology …, 2016 - Springer
Thraustochytrids have been applied for industrial production of the omega-3 fatty acid
docosahexaenoic (DHA) since the 1990s. During more than 20 years of research on this …

Development of a cooperative two-factor adaptive-evolution method to enhance lipid production and prevent lipid peroxidation in Schizochytrium sp.

XM Sun, LJ Ren, ZQ Bi, XJ Ji, QY Zhao, L Jiang… - Biotechnology for …, 2018 - Springer
Background Schizochytrium sp. is a marine microalga with great potential as a promising
sustainable source of lipids rich in docosahexaenoic acid (DHA). This organism's lipid …

Low-temperature effects on docosahexaenoic acid biosynthesis in Schizochytrium sp. TIO01 and its proposed underlying mechanism

F Hu, AL Clevenger, P Zheng, Q Huang… - Biotechnology for …, 2020 - Springer
Background Schizochytrium species are known for their abundant production of
docosahexaenoic acid (DHA). Low temperatures can promote the biosynthesis of …

Physiological and de novo transcriptome analysis of the fermentation mechanism of Cerasus sachalinensis roots in response to short-term waterlogging

P Zhang, D Lyu, L Jia, J He, S Qin - BMC genomics, 2017 - Springer
Background Cerasus sachalinensis is widely used in cool regions as a sweet cherry
rootstock and is known for its sensitivity to soil waterlogging and waterlogging stress …

Overexpression of glucose-6-phosphate dehydrogenase enhanced the polyunsaturated fatty acid composition of Aurantiochytrium sp. SD116

GZ Cui, Z Ma, YJ Liu, Y Feng, Z Sun, Y Cheng, X Song… - Algal research, 2016 - Elsevier
Abstract Aurantiochytrium sp.(Thraustochytriaceae, Stramenopiles) is a highly promising
polyunsaturated fatty acid (PUFA) resource due to its high docosahexaenoic acid (DHA) …

Transcriptome and gene expression analysis of docosahexaenoic acid producer Schizochytrium sp. under different oxygen supply conditions

ZQ Bi, LJ Ren, XC Hu, XM Sun, SY Zhu, XJ Ji… - Biotechnology for …, 2018 - Springer
Background Schizochytrium sp. is a promising strain for the production of docosahexaenoic
acid (DHA)-rich oil and biodiesel, and has been widely used in the food additive and …

Rewiring metabolic network by chemical modulator based laboratory evolution doubles lipid production in Crypthecodinium cohnii

J Diao, X Song, J Cui, L Liu, M Shi, F Wang… - Metabolic …, 2019 - Elsevier
Dietary omega-3 long-chain polyunsaturated fatty acids docosahexaenoic acid (DHA, C22:
6) can be synthesized in microalgae Crypthecodinium cohnii; however, its productivity is still …