The Alzheimer's Association appropriate use recommendations for blood biomarkers in Alzheimer's disease

O Hansson, RM Edelmayer, AL Boxer… - Alzheimer's & …, 2022 - Wiley Online Library
Blood‐based markers (BBMs) have recently shown promise to revolutionize the diagnostic
and prognostic work‐up of Alzheimer's disease (AD), as well as to improve the design of …

The amyloid cascade hypothesis: an updated critical review

KP Kepp, NK Robakis, PF Høilund-Carlsen, SL Sensi… - Brain, 2023 - academic.oup.com
Results from recent clinical trials of antibodies that target amyloid-β (Aβ) for Alzheimer's
disease have created excitement and have been heralded as corroboration of the amyloid …

Highly accurate blood test for Alzheimer's disease is similar or superior to clinical cerebrospinal fluid tests

NR Barthélemy, G Salvadó, SE Schindler, Y He… - Nature medicine, 2024 - nature.com
With the emergence of Alzheimer's disease (AD) disease-modifying therapies, identifying
patients who could benefit from these treatments becomes critical. In this study, we …

Gut microbiome composition may be an indicator of preclinical Alzheimer's disease

AL Ferreiro, JH Choi, J Ryou, EP Newcomer… - Science translational …, 2023 - science.org
Alzheimer's disease (AD) pathology is thought to progress from normal cognition through
preclinical disease and ultimately to symptomatic AD with cognitive impairment. Recent work …

Acceptable performance of blood biomarker tests of amyloid pathology—recommendations from the Global CEO Initiative on Alzheimer's Disease

SE Schindler, D Galasko, AC Pereira… - Nature Reviews …, 2024 - nature.com
Anti-amyloid treatments for early symptomatic Alzheimer disease have recently become
clinically available in some countries, which has greatly increased the need for biomarker …

Biomarkers for neurodegenerative diseases

O Hansson - Nature medicine, 2021 - nature.com
Biomarkers for neurodegenerative diseases are needed to improve the diagnostic workup in
the clinic but also to facilitate the development and monitoring of effective disease-modifying …

Anti-amyloid antibody therapies in Alzheimer's disease

R Perneczky, F Jessen, T Grimmer, J Levin, A Flöel… - Brain, 2023 - academic.oup.com
After years of failed attempts to develop a disease-modifying therapy for Alzheimer's
disease, consistent evidence in support of clinical efficacy was finally presented for a …

Machine learning for dementia prediction: a systematic review and future research directions

A Javeed, AL Dallora, JS Berglund, A Ali, L Ali… - Journal of medical …, 2023 - Springer
Abstract Nowadays, Artificial Intelligence (AI) and machine learning (ML) have successfully
provided automated solutions to numerous real-world problems. Healthcare is one of the …

Blood‐based biomarkers for Alzheimer's disease

A Leuzy, N Mattsson‐Carlgren, S Palmqvist… - EMBO molecular …, 2022 - embopress.org
Neurodegenerative disorders such as Alzheimer's disease (AD) represent a mounting public
health challenge. As these diseases are difficult to diagnose clinically, biomarkers of …

[HTML][HTML] Aducanumab: appropriate use recommendations

J Cummings, P Aisen, LG Apostolova, A Atri… - The journal of …, 2021 - Elsevier
Aducanumab has been approved by the US Food and Drug Administration for treatment of
Alzheimer's disease (AD). Clinicians require guidance on the appropriate use of this new …