Atopic dermatitis (AD) is an important chronic or relapsing inflammatory skin disease that
often precedes asthma and allergic disorders. New insights into the genetics and …

A genetic basis for atopic dermatitis (AD) has long been recognized. Historic documents
allude to family history of disease as a risk factor. Before characterization of the human …

Background Albuterol is the first-line asthma medication used in diverse populations.
Although DNA methylation (DNAm) is an epigenetic mechanism involved in asthma and …

Mechanical ventilation is a life-saving intervention in critically ill patients with respiratory
failure due to acute respiratory distress syndrome (ARDS). Paradoxically, mechanical …

The smooth muscle isoform of myosin light chain kinase (MLCK) is a Ca 2+-calmodulin-
activated kinase that is found in many tissues. It is particularly important for regulating …

Nonmuscle myosin light chain kinase (nmMLCK), a multi-functional cytoskeletal protein
critical to vascular homeostasis, is highly regulated by tyrosine phosphorylation. We …

Rationale: Prolonged exposure to 100% O2 causes hyperoxic acute lung injury (HALI),
characterized by alveolar epithelial cell injury and death. We previously demonstrated that …

The pulmonary endothelial cell forms a critical semi-permeable barrier between the vascular
and interstitial space. As part of the blood-gas barrier in the lung, the endothelium plays a …

Significance: Acute respiratory distress syndrome (ARDS) is a severe, highly heterogeneous
critical illness with staggering mortality that is influenced by environmental factors, such as …

NRF2 regulates cellular redox homeostasis, metabolic balance, and proteostasis by forming
a dimer with small musculoaponeurotic fibrosarcoma proteins (sMAFs) and binding to …