Pathogenicity and virulence of Aspergillus fumigatus

K Earle, C Valero, DP Conn, G Vere, PC Cook… - Virulence, 2023 - Taylor & Francis
Pulmonary infections caused by the mould pathogen Aspergillus fumigatus are a major
cause of morbidity and mortality globally. Compromised lung defences arising from …

Antifungal resistance, combinations and pipeline: oh my!

KR Stover, BK Hawkins, JM Keck, KE Barber… - Drugs in …, 2023 - pmc.ncbi.nlm.nih.gov
Invasive fungal infections are a strong contributor to healthcare costs, morbidity and
mortality, especially amongst hospitalized patients. Historically, Candida was responsible for …

Multi-omics reveals the increased biofilm formation of Salmonella Typhimurium M3 by the induction of tetracycline at sub-inhibitory concentrations

L Yuan, L Fan, H Dai, G He, X Zheng, S Rao… - Science of the Total …, 2023 - Elsevier
Exposure to sub-inhibitory concentrations (sub-MICs) of antibiotics could induce the biofilm
formation of microorganisms, but its underlying mechanisms still remain elusive. In the …

Unsaturated fatty acid perturbation combats emerging triazole antifungal resistance in the human fungal pathogen Aspergillus fumigatus

C Gutierrez-Perez, C Puerner, JT Jones, S Vellanki… - Mbio, 2024 - journals.asm.org
Contemporary antifungal therapies utilized to treat filamentous fungal infections are inhibited
by intrinsic and emerging drug resistance. Consequently, there is an urgent need to develop …

Filamentous fungal biofilms: Conserved and unique aspects of extracellular matrix composition, mechanisms of drug resistance and regulatory networks in Aspergillus …

S Liu, F Le Mauff, DC Sheppard, S Zhang - npj Biofilms and …, 2022 - nature.com
The filamentous fungus Aspergillus fumigatus is an ubiquitous mold that can cause invasive
pulmonary infections in immunocompromised patients. Within the lung, A. fumigatus forms …

Amino sugars influence Aspergillus fumigatus cell wall polysaccharide biosynthesis, and biofilm formation through interfering galactosaminogalactan deacetylation

R He, P Wei, AS Odiba, L Gao, S Usman, X Gong… - Carbohydrate …, 2024 - Elsevier
Aspergillus fumigatus is a ubiquitous fungal pathogen responsible for a significant number
of deaths annually due to invasive aspergillosis infection. While the utilization of diverse …

The heat shock transcription factor HsfA plays a role in membrane lipids biosynthesis connecting thermotolerance and unsaturated fatty acid metabolism in Aspergillus …

JHTM Fabri, MC Rocha, CM Fernandes… - Microbiology …, 2023 - journals.asm.org
Thermotolerance is a remarkable virulence attribute of Aspergillus fumigatus, but the
consequences of heat shock (HS) to the cell membrane of this fungus are unknown …

Recent developments in Aspergillus fumigatus research: diversity, drugs, and disease

N Kordana, A Johnson, K Quinn, JJ Obar… - Microbiology and …, 2025 - journals.asm.org
Advances in modern medical therapies for many previously intractable human diseases
have improved patient outcomes. However, successful disease treatment outcomes are …

Assessing the intracellular primary metabolic profile of Trichoderma reesei and Aspergillus niger grown on different carbon sources

GP Borin, JVC Oliveira - Frontiers in Fungal Biology, 2022 - frontiersin.org
Trichoderma reesei and Aspergillus niger are efficient biological platforms for the production
of various industrial products, including cellulases and organic acids. Nevertheless, despite …