Inferring allele-specific copy number aberrations and tumor phylogeography from spatially resolved transcriptomics
Analyzing somatic evolution within a tumor over time and across space is a key challenge in
cancer research. Spatially resolved transcriptomics (SRT) measures gene expression at …
cancer research. Spatially resolved transcriptomics (SRT) measures gene expression at …
Cancer phylogenetic inference using copy number alterations detected from DNA sequencing data
B Lu - Cancer pathogenesis and therapy, 2025 - mednexus.org
Cancer is an evolutionary process involving the accumulation of diverse somatic mutations
and clonal evolution over time. Phylogenetic inference from samples obtained from an …
and clonal evolution over time. Phylogenetic inference from samples obtained from an …
The Evolutionary Forest of Pancreatic Cancer
The genomic features of pancreatic ductal adenocarcinoma (PDAC) have been well
described, yet the evolutionary contexts within which these features occur remain …
described, yet the evolutionary contexts within which these features occur remain …
Karyotype Evolution in Response to Chemoradiotherapy and Upon Recurrence of Esophageal Adenocarcinomas.
K van der Sluis, JW Sandick, WJ Koemans… - bioRxiv, 2024 - biorxiv.org
The genome of esophageal adenocarcinoma (EAC) is highly unstable and might evolve
over time. Here, we track karyotype evolution in EACs in response to treatment and upon …
over time. Here, we track karyotype evolution in EACs in response to treatment and upon …
[PDF][PDF] Transcriptome-based characterization of treatment resistance mechanisms in high-grade serous carcinoma
S Jamalzadeh - 2024 - helda.helsinki.fi
Cancer, characterized by its complex and heterogeneous nature, poses a significant global
health challenge, with drug resistance acting as a major impediment to effective treatment …
health challenge, with drug resistance acting as a major impediment to effective treatment …