Cytokine targets in the brain: impact on neurotransmitters and neurocircuits
Increasing attention has been paid to the role of inflammation in a host of illnesses including
neuropsychiatric disorders such as depression and anxiety. Activation of the inflammatory …
neuropsychiatric disorders such as depression and anxiety. Activation of the inflammatory …
Inflammation and its discontents: the role of cytokines in the pathophysiology of major depression
AH Miller, V Maletic, CL Raison - Biological psychiatry, 2009 - Elsevier
Recognition that inflammation may represent a common mechanism of disease has been
extended to include neuropsychiatric disorders including major depression. Patients with …
extended to include neuropsychiatric disorders including major depression. Patients with …
[HTML][HTML] Psilocybin induces acute and persisting alterations in immune status in healthy volunteers: An experimental, placebo-controlled study
Patients characterized by stress-related disorders such as depression display elevated
circulating concentrations of pro-inflammatory cytokines and a hyperactive HPA axis …
circulating concentrations of pro-inflammatory cytokines and a hyperactive HPA axis …
Functional biomarkers of depression: diagnosis, treatment, and pathophysiology
Major depressive disorder (MDD) is a heterogeneous illness for which there are currently no
effective methods to objectively assess severity, endophenotypes, or response to treatment …
effective methods to objectively assess severity, endophenotypes, or response to treatment …
The longitudinal effects of depression on physical activity
B Roshanaei-Moghaddam, WJ Katon… - General hospital psychiatry, 2009 - Elsevier
OBJECTIVES: It has been posited that depression and sedentary lifestyle have bidirectional
relationships. Although the role of baseline physical activity as a risk factor for emerging …
relationships. Although the role of baseline physical activity as a risk factor for emerging …
Interleukin-1β: a new regulator of the kynurenine pathway affecting human hippocampal neurogenesis
Increased inflammation and reduced neurogenesis have been associated with the
pathophysiology of major depression. Here, we show for the first time how IL-1β, a pro …
pathophysiology of major depression. Here, we show for the first time how IL-1β, a pro …
Serum and plasma BDNF levels in major depression: a replication study and meta-analyses
L Bocchio-Chiavetto, V Bagnardi… - The World Journal of …, 2010 - Taylor & Francis
Objectives. Alterations of BDNF signalling in major depression (MD) are supported by
studies demonstrating decreased levels of the neurotrophin serum and plasma content in …
studies demonstrating decreased levels of the neurotrophin serum and plasma content in …
DNA methylation profiles of the brain-derived neurotrophic factor (BDNF) gene as a potent diagnostic biomarker in major depression
M Fuchikami, S Morinobu, M Segawa, Y Okamoto… - PloS one, 2011 - journals.plos.org
Major depression, because of its recurring and life-threatening nature, is one of the top 10
diseases for global disease burden. Major depression is still diagnosed on the basis of …
diseases for global disease burden. Major depression is still diagnosed on the basis of …
Depression as a systemic syndrome: map** the feedback loops of major depressive disorder
BackgroundDepression is a complex public health problem with considerable variation in
treatment response. The systemic complexity of depression, or the feedback processes …
treatment response. The systemic complexity of depression, or the feedback processes …
Stress, depression and cardiovascular dysregulation: a review of neurobiological mechanisms and the integration of research from preclinical disease models
AJ Grippo, AK Johnson - Stress, 2009 - Taylor & Francis
Bidirectional associations between mood disorders and cardiovascular diseases are
extensively documented. However, the precise physiological and biochemical mechanisms …
extensively documented. However, the precise physiological and biochemical mechanisms …