Cell death is a fundamental physiological process in all living organisms. Its roles extend
from embryonic development, organ maintenance, and aging to the coordination of immune …

NF-κB pathway consists of canonical and non-canonical pathways. The canonical NF-κB is
activated by various stimuli, transducing a quick but transient transcriptional activity, to …

For over three decades, a mainstay and goal of clinical oncology has been the development
of therapies promoting the effective elimination of cancer cells by apoptosis. This …

Reactive oxygen species (ROS) are key signaling molecules that play an important role in
the progression of inflammatory disorders. An enhanced ROS generation by …

Twelve regulated cell death programs have been described. We review in detail the basic
biology of nine including death receptor-mediated apoptosis, death receptor-mediated …

Apoptosis is a form of programmed cell death that results in the orderly and efficient removal
of damaged cells, such as those resulting from DNA damage or during development …

Apoptosis—the regulated destruction of a cell—is a complicated process. The decision to
die cannot be taken lightly, and the activity of many genes influence a cell's likelihood of …

REVIEW Apoptosis, an evolutionarily conserved form of cell suicide, requires specialized
machinery. The central component of this machinery is a proteolytic system involving a …

Beneath the complexity and idiopathy of every cancer lies a limited number of'mission
critical'events that have propelled the tumour cell and its progeny into uncontrolled …

Apoptosis induced by TNF-receptor I (TNFR1) is thought to proceed via recruitment of the
adaptor FADD and caspase-8 to the receptor complex. TNFR1 signaling is also known to …