ATPases associated with diverse cellular activities (AAA+ proteins) are macromolecular
machines that convert the chemical energy contained in ATP molecules into powerful …

The endoplasmic reticulum (ER) is a large, dynamic, and multifunctional organelle. ER
protein homeostasis is essential for the coordination of its diverse functions and depends on …

Hijacking the cellular protein degradation system offers unique opportunities for drug
discovery, as exemplified by proteolysis-targeting chimeras. Despite their great promise for …

Protein aggregation occurs as a consequence of perturbations in protein homeostasis that
can be triggered by environmental and cellular stresses. The accumulation of protein …

Endosperm is the main storage organ in cereal grain and determines grain yield and quality.
The molecular mechanisms of heat shock proteins in regulating starch biosynthesis and …

ClpXP is an ATP-dependent protease in which the ClpX AAA+ motor binds, unfolds, and
translocates specific protein substrates into the degradation chamber of ClpP. We present …

Proteolysis-targeting chimeras (PROTACs) represent a new therapeutic modality involving
selectively directing disease-causing proteins for degradation through proteolytic systems …

Since the release of AlphaFold, researchers have actively refined its predictions and
attempted to integrate it into existing pipelines for determining protein structures. These …

p97/valosin-containing protein is an essential eukaryotic AAA+ ATPase with diverse
functions including protein homeostasis, membrane remodeling, and chromatin regulation …

ClpP is a highly conserved serine protease that is a critical enzyme in maintaining protein
homeostasis and is an important drug target in pathogenic bacteria and various cancers. In …