The current diagnostic pathway for prostate cancer has resulted in overdiagnosis and
consequent overtreatment as well as underdiagnosis and missed diagnoses in many men …

Objectives To present historical and contemporary hypotheses on the pathogenesis of
benign prostatic hyperplasia (BPH), and the potential implications for current medical …

The practice of radical prostatectomy for treating prostate cancer has evolved remarkably
since its general introduction around 1900. Initially described using a perineal approach, the …

Prostate cancer is the most frequent nonskin cancer and second most common cause of
cancer-related deaths in man. Prostate cancer is a clinically heterogeneous disease with …

Background Castration‐insensitive epithelial progenitors capable of regenerating the
prostate have been proposed to be concentrated in the proximal region based on facultative …

Benign prostatic hyperplasia (BPH) is a common male condition that impacts many men's
quality of life by generating lower urinary tract symptoms (LUTS). In recent years …

Objective Proliferative nodular formation represents a characteristic pathological feature of
benign prostatic hyperplasia (BPH) and serves as the primary cause for prostate volume …

Senescent cells accumulate with age in all tissues. Although senescent cells undergo cell-
cycle arrest, these cells remain metabolically active and their secretome—known as the …

Benign prostatic hyperplasia (BPH) is a multifactorial disease in which abnormal growth
factor activation and embryonic reawakening are considered important factors. Here we …

Benign prostatic hyperplasia (BPH) and associated lower urinary tract symptoms are
common clinical concerns that affect aging men all over the world. The underlying molecular …