Intercellular signaling molecules, known as morphogens, act at a long range in develo**
tissues to provide spatial information and control properties such as cell fate and tissue …

Self-organization is pervasive in development, from symmetry breaking in the early embryo
to tissue patterning and morphogenesis. For a few model systems, the underlying molecular …

Multiplexed RNA sequencing in individual cells is transforming basic and clinical life
sciences,,–. Often, however, tissues must first be dissociated, and crucial information about …

Organisms acquire and use information from their environment to guide their behaviour.
However, it is unclear whether this information quantitatively limits their performance at …

The Free Energy Principle and Active Inference Framework (FEP-AI) begins with the
understanding that thermodynamically-open systems must regulate environmental …

Gene expression is inherently noisy, posing a challenge to understanding how precise and
reproducible patterns of gene expression emerge in mammals. Here we investigate this …

A key challenge in molecular biology is to decipher the map** of protein sequence to
function. To perform this map** requires the identification of sequence features most …

Metazoan embryos develop from a single cell into three-dimensional structured organisms
while groups of genetically identical cells attain specialized identities. Cells of the …

Half a century after Lewis Wolpert's seminal conceptual advance on how cellular fates
distribute in space, we provide a brief historical perspective on how the concept of positional …

Predicting how interactions between transcription factors and regulatory DNA sequence
dictate rates of transcription and, ultimately, drive developmental outcomes remains an open …