Applications of focused ultrasound in the brain: from thermoablation to drug delivery

Y Meng, K Hynynen, N Lipsman - Nature Reviews Neurology, 2021 - nature.com
Focused ultrasound (FUS) is a disruptive medical technology, and its implementation in the
clinic represents the culmination of decades of research. Lying at the convergence of …

Essential tremor

T Welton, F Cardoso, JA Carr, LL Chan… - Nature reviews Disease …, 2021 - nature.com
Essential tremor (ET) is one of the most common movement disorders, with a reported> 60
million affected individuals worldwide. The definition and underlying pathophysiology of ET …

Current and future directions of deep brain stimulation for neurological and psychiatric disorders: JNSPG 75th Anniversary Invited Review Article

DJ Lee, CS Lozano, RF Dallapiazza… - Journal of neurosurgery, 2019 - thejns.org
Deep brain stimulation (DBS) has evolved considerably over the past 4 decades. Although it
has primarily been used to treat movement disorders such as Parkinson's disease, essential …

Cellular, molecular, and clinical mechanisms of action of deep brain stimulation—a systematic review on established indications and outlook on future developments

M Jakobs, A Fomenko, AM Lozano… - EMBO molecular …, 2019 - embopress.org
Deep brain stimulation (DBS) has been successfully used to treat movement disorders, such
as Parkinson's disease, for more than 25 years and heralded the advent of electrical …

Bilateral focused ultrasound thalamotomy for essential tremor (BEST‐FUS phase 2 trial)

C Iorio‐Morin, K Yamamoto, C Sarica… - Movement …, 2021 - Wiley Online Library
Background In patients with medically refractory essential tremor, unilateral magnetic
resonance–guided focused ultrasound thalamotomy can improve contralateral tremor …

[HTML][HTML] Deep brain stimulation for the management of refractory neurological disorders: a comprehensive review

JP Rissardo, NM Vora, I Tariq, A Mujtaba, ALF Caprara - Medicina, 2023 - mdpi.com
In recent decades, deep brain stimulation (DBS) has been extensively studied due to its
reversibility and significantly fewer side effects. DBS is mainly a symptomatic therapy, but the …

Comparative connectivity correlates of dystonic and essential tremor deep brain stimulation

T Tsuboi, JK Wong, RS Eisinger, L Okromelidze… - Brain, 2021 - academic.oup.com
The pathophysiology of dystonic tremor and essential tremor remains partially understood.
In patients with medication-refractory dystonic tremor or essential tremor, deep brain …

[HTML][HTML] Managing essential tremor

F Hopfner, G Deuschl - Neurotherapeutics, 2020 - Elsevier
Essential tremor is one of the most common tremor syndromes. According to the recent
tremor classification, tremor as a symptom is defined as an involuntary, rhythmic, oscillatory …

[HTML][HTML] Sustained reduction of essential tremor with low-power non-thermal transcranial focused ultrasound stimulations in humans

T Bancel, B Béranger, M Daniel, M Didier, M Santin… - Brain Stimulation, 2024 - Elsevier
Background Transcranial ultrasound stimulation (TUS) is a non-invasive brain stimulation
technique; when skull aberrations are compensated for, this technique allows, with …

[HTML][HTML] The role of the motor thalamus in deep brain stimulation for essential tremor

C Neudorfer, K Kultas-Ilinsky, I Ilinsky, S Paschen… - …, 2024 - Elsevier
The advent of next-generation technology has significantly advanced the implementation
and delivery of Deep Brain Stimulation (DBS) for Essential Tremor (ET), yet controversies …