Long‐COVID syndrome‐associated brain fog and chemofog: Luteolin to the rescue

TC Theoharides, C Cholevas, K Polyzoidis… - Biofactors, 2021 - Wiley Online Library
COVID‐19 leads to severe respiratory problems, but also to long‐COVID syndrome
associated primarily with cognitive dysfunction and fatigue. Long‐COVID syndrome …

[HTML][HTML] The vagus nerve at the interface of the microbiota-gut-brain axis

B Bonaz, T Bazin, S Pellissier - Frontiers in neuroscience, 2018 - frontiersin.org
The microbiota, the gut, and the brain communicate through the microbiota-gut-brain axis in
a bidirectional way that involves the autonomic nervous system. The vagus nerve (VN), the …

Alopecia areata: a review of disease pathogenesis

F Rajabi, LA Drake, MM Senna… - British Journal of …, 2018 - academic.oup.com
Background Alopecia areata is a disorder that results in nonscarring hair loss. The
psychological impact can be significant, leading to feelings of depression and social …

Brain and peripheral atypical inflammatory mediators potentiate neuroinflammation and neurodegeneration

D Kempuraj, R Thangavel, GP Selvakumar… - Frontiers in cellular …, 2017 - frontiersin.org
Neuroinflammatory response is primarily a protective mechanism in the brain. However,
excessive and chronic inflammatory responses can lead to deleterious effects involving …

Stress-induced interaction of skin immune cells, hormones, and neurotransmitters

N Pondeljak, L Lugović-Mihić - Clinical therapeutics, 2020 - Elsevier
Purpose Although scientific articles mention the impact of psychological stress on skin
diseases, few review the latest research on factors involved in this correlation. The skin …

Role of SARS-CoV-2 spike-protein-induced activation of microglia and mast cells in the pathogenesis of neuro-COVID

TC Theoharides, D Kempuraj - Cells, 2023 - mdpi.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes coronavirus
disease 2019 (COVID-19). About 45% of COVID-19 patients experience several symptoms a …

[HTML][HTML] Mast cells and inflammation

TC Theoharides, KD Alysandratos, A Angelidou… - … et Biophysica Acta (BBA …, 2012 - Elsevier
Mast cells are well known for their role in allergic and anaphylactic reactions, as well as their
involvement in acquired and innate immunity. Increasing evidence now implicates mast cells …

Potential mechanisms underlying centralized pain and emerging therapeutic interventions

OC Eller-Smith, AL Nicol… - Frontiers in cellular …, 2018 - frontiersin.org
Centralized pain syndromes are associated with changes within the central nervous system
that amplify peripheral input and/or generate the perception of pain in the absence of a …

Key role of CRF in the skin stress response system

AT Slominski, MA Zmijewski, B Zbytek… - Endocrine …, 2013 - academic.oup.com
The discovery of corticotropin-releasing factor (CRF) or CRH defining the upper regulatory
arm of the hypothalamic-pituitary-adrenal (HPA) axis, along with the identification of the …

Mast cell mediation of visceral sensation and permeability in irritable bowel syndrome

WL Hasler, G Grabauskas, P Singh… - …, 2022 - Wiley Online Library
Abnormalities of mast cell structure or function may play prominent roles in irritable bowel
syndrome (IBS) symptom genesis. Mast cells show close apposition to sensory nerves and …