[HTML][HTML] Recent advances in visible light-activated radical coupling reactions triggered by (i) ruthenium,(ii) iridium and (iii) organic photoredox agents
Photoredox chemistry with organic or transition metal agents has been reviewed in earlier
years, but such is the pace of progress that we will overlap very little with earlier …
years, but such is the pace of progress that we will overlap very little with earlier …
Strategies to generate nitrogen-centered radicals that may rely on photoredox catalysis: development in reaction methodology and applications in organic synthesis
For more than 70 years, nitrogen-centered radicals have been recognized as potent
synthetic intermediates. This review is a survey designed for use by chemists engaged in …
synthetic intermediates. This review is a survey designed for use by chemists engaged in …
Visible light-driven radical-mediated C–C bond cleavage/functionalization in organic synthesis
XY Yu, JR Chen, WJ **ao - Chemical Reviews, 2020 - ACS Publications
Thermal C–C bond cleavage reactions allow the construction of structurally diverse
molecular skeletons via predictable and efficient bond reorganizations. Visible light …
molecular skeletons via predictable and efficient bond reorganizations. Visible light …
Strain-release photocatalysis
The concept of strain in organic compounds is as old as modern organic chemistry and was
initially introduced to justify the synthetic setbacks along the synthesis of small ring systems …
initially introduced to justify the synthetic setbacks along the synthesis of small ring systems …
Multicomponent reactions and photo/electrochemistry join forces: atom economy meets energy efficiency
Visible-light photoredox catalysis has been regarded as an extremely powerful tool in
organic chemistry, bringing the spotlight back to radical processes. The versatility of …
organic chemistry, bringing the spotlight back to radical processes. The versatility of …
2-Oxabicyclo[2.1.1]hexanes as saturated bioisosteres of the ortho-substituted phenyl ring
A Denisenko, P Garbuz, NM Voloshchuk, Y Holota… - Nature Chemistry, 2023 - nature.com
The ortho-substituted phenyl ring is a basic structural element in chemistry. It is found in
more than three hundred drugs and agrochemicals. During the past decade, scientists have …
more than three hundred drugs and agrochemicals. During the past decade, scientists have …
Exploiting the sp2 character of bicyclo[1.1.1]pentyl radicals in the transition-metal-free multi-component difunctionalization of [1.1.1]propellane
Strained bicyclic substructures are increasingly relevant in medicinal chemistry discovery
research because of their role as bioisosteres. Over the last decade, the successful use of …
research because of their role as bioisosteres. Over the last decade, the successful use of …
Practical and Facile Access to Bicyclo[3.1.1]heptanes: Potent Bioisosteres of meta-Substituted Benzenes
T Iida, J Kanazawa, T Matsunaga… - Journal of the …, 2022 - ACS Publications
There is increasing interest in replacement of the planar aromatic rings of drug candidates
with three-dimensional caged scaffolds in order to improve the physical properties, but …
with three-dimensional caged scaffolds in order to improve the physical properties, but …
Dicarbofunctionalization of [1.1. 1] propellane enabled by nickel/photoredox dual catalysis: one-step multicomponent strategy for the synthesis of BCP-aryl derivatives
Bicyclo [1.1. 1] pentane (BCP) motifs as para-disubstituted aryl bioisosteres are playing an
emerging role in pharmaceutical, agrochemical, and materials chemistry. The vast majority …
emerging role in pharmaceutical, agrochemical, and materials chemistry. The vast majority …
An intramolecular coupling approach to alkyl bioisosteres for the synthesis of multisubstituted bicycloalkyl boronates
Abstract Bicyclic hydrocarbons, and bicyclo [1.1. 1] pentanes (BCPs) in particular, are
playing an emerging role as saturated bioisosteres in pharmaceutical, agrochemical and …
playing an emerging role as saturated bioisosteres in pharmaceutical, agrochemical and …