Escherichia coli is considered to be the best-known microorganism given the large number
of published studies detailing its genes, its genome and the biochemical functions of its …

Given the functional interdependencies between the molecular components in a human cell,
a disease is rarely a consequence of an abnormality in a single gene, but reflects the …

The ultimate proof of our understanding of natural or technological systems is reflected in
our ability to control them. Although control theory offers mathematical tools for steering …

Despite considerable progress in genome-and proteome-based high-throughput screening
methods and in rational drug design, the increase in approved drugs in the past decade did …

The dominant paradigm in drug discovery is the concept of designing maximally selective
ligands to act on individual drug targets. However, many effective drugs act via modulation …

The problem of reconstructing nonlinear and complex dynamical systems from measured
data or time series is central to many scientific disciplines including physical, biological …

The success of new scientific areas can be assessed by their potential in contributing to new
theoretical approaches and in applications to real-world problems. Complex networks have …

The control of complex networks is of paramount importance in areas as diverse as
ecosystem management, emergency response and cell reprogramming. A fundamental …

The genome‐scale model (GEM) of metabolism in the bacterium Escherichia coli K‐12 has
been in development for over a decade and is now in wide use. GEM‐enabled studies of E …

Mixed microbial communities exhibit emergent biochemical properties not found in clonal
monocultures. We report a new type of synthetic genetic interaction, synthetic mutualism in …