Progress in the design of G-quadruplex (G4) binding ligands relies on the availability of
approaches that assess the binding mode and nature of the interactions between G4 …

Nucleic acids have been among the first targets for antitumor drugs and antibiotics. With the
unveiling of new biological roles in regulation of gene expression, specific DNA and RNA …

Organic small molecules that can recognize and bind to G-quadruplex and i-Motif nucleic
acids have great potential as selective drugs or as tools in drug target discovery programs …

While vaccines have been highly successful in protecting against various infections, there
are still many high‐priority pathogens for which there are no clinically approved …

Short tandem repeats are inherently unstable during DNA replication depending on repeat
length, and the expansion of the repeat length in the human genome is responsible for …

G-quadruplexes turned out to be important targets for the development of novel targeted
anticancer/antiviral therapies. More than 3000 G-quadruplex small-molecule ligands have …

The polymorphic formation of G-quadruplex brings more attentions, because changes of
formation sites affect many physiological processes, like telomere maintenance …

G-quadruplexes (GQs) are non-canonical DNA structures composed of stacks of stabilized G-
tetrads. GQs play an important role in a variety of biological processes and may form at …

Left-handed G-quadruplexes (LHG4s) belong to a class of recently discovered noncanonical
DNA structures under the larger umbrella of G-quadruplex DNAs (G4s). The biological …

Modulating crucial biological processes such as gene regulation, aging, and relationship to
globally important human health issues such as cancer has significantly brought …