Metabolic reprogramming is one of the main characteristics of malignant tumors, which is
due to the flexible changes of cell metabolism that can meet the needs of cell growth and …

Abstract Ferroptosis suppressor protein 1 (FSP1) is one of the main regulatory molecules of
ferroptosis. FSP1 functions through the FSP1-coenzyme Q10 (CoQ10)-NAD (P) H axis and …

Background & Aims Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-
related deaths worldwide, but there is a deficiency of early diagnosis biomarkers and …

Tumor-infiltrating myeloid cells (TIMs) are crucial cell populations involved in tumor immune
escape, and their functions are regulated by multiple epigenetic mechanisms. The precise …

Abstract Abnormal N6-methyladenosine (m6A) modification is closely associated with the
occurrence, development, progression and prognosis of cancer, and aberrant m6A …

Cancer stem cells (CSCs), initially identified in leukemia in 1994, constitute a distinct subset
of tumor cells characterized by surface markers such as CD133, CD44, and ALDH. Their …

The role of N 6-methyladenosine (m6A) modifications in renal diseases is largely unknown.
Here, we characterized the role of N 6-adenosine-methyltransferase-like 3 (METTL3), whose …

Cancer therapy resistance is the main cause of cancer treatment failure. The mechanism of
therapy resistance is a hot topic in epigenetics. As one of the most common RNA …

Metabolic enzymes have an indispensable role in metabolic reprogramming, and their
aberrant expression or activity has been associated with chemosensitivity. Hence, targeting …

Microbiota-host interactions play critical roles in colorectal cancer (CRC) progression,
however, the underlying mechanisms remain elusive. Here, we uncover that Fusobacterium …