Solid-state nanopore sensors

L Xue, H Yamazaki, R Ren, M Wanunu… - Nature Reviews …, 2020 - nature.com
Nanopore-based sensors have established themselves as a prominent tool for solution-
based, single-molecule analysis of the key building blocks of life, including nucleic acids …

In situ solid-state nanopore fabrication

JP Fried, JL Swett, BP Nadappuram, JA Mol… - Chemical Society …, 2021 - pubs.rsc.org
Nanopores in solid-state membranes are promising for a wide range of applications
including DNA sequencing, ultra-dilute analyte detection, protein analysis, and polymer data …

Plasmonic‐nanopore biosensors for superior single‐molecule detection

JD Spitzberg, A Zrehen, XF van Kooten… - Advanced …, 2019 - Wiley Online Library
Plasmonic and nanopore sensors have separately received much attention for achieving
single‐molecule precision. A plasmonic “hotspot” confines and enhances optical excitation …

Fabrication and practical applications of molybdenum disulfide nanopores

M Graf, M Lihter, M Thakur, V Georgiou, J Topolancik… - Nature protocols, 2019 - nature.com
Among the different developed solid-state nanopores, nanopores constructed in a
monolayer of molybdenum disulfide (MoS2) stand out as powerful devices for single …

Optical nanopore sensors for quantitative analysis

JP Fried, Y Wu, RD Tilley, JJ Gooding - Nano Letters, 2022 - ACS Publications
Nanopore sensors have received significant interest for the detection of clinically important
biomarkers with single-molecule resolution. These sensors typically operate by detecting …

Single-file translocation dynamics of SDS-denatured, whole proteins through sub-5 nm solid-state nanopores

N Soni, N Freundlich, S Ohayon, D Huttner, A Meller - ACS nano, 2022 - ACS Publications
The ability to routinely identify and quantify the complete proteome from single cells will
greatly advance medicine and basic biology research. To meet this challenge of single-cell …

Quantification of mRNA expression using single-molecule nanopore sensing

Y Rozevsky, T Gilboa, XF van Kooten, D Kobelt… - ACS …, 2020 - ACS Publications
RNA quantification methods are broadly used in life science research and in clinical
diagnostics. Currently, real-time reverse transcription polymerase chain reaction (RT-qPCR) …

Photothermally assisted thinning of silicon nitride membranes for ultrathin asymmetric nanopores

H Yamazaki, R Hu, Q Zhao, M Wanunu - ACS nano, 2018 - ACS Publications
Sculpting solid-state materials at the nanoscale is an important step in the manufacturing of
numerous types of sensor devices, in particular solid-state nanopore sensors. Here we …

Four aspects about solid‐state nanopores for protein sensing: fabrication, sensitivity, selectivity, and durability

R Hu, X Tong, Q Zhao - Advanced healthcare materials, 2020 - Wiley Online Library
Solid‐state nanopores are a mimic of innate biological nanopores embedded on lipid
membranes. They are fabricated on thin suspended layers of synthetic materials that provide …

Lithography-based fabrication of nanopore arrays in freestanding SiN and graphene membranes

DV Verschueren, W Yang, C Dekker - Nanotechnology, 2018 - iopscience.iop.org
We report a simple and scalable technique for the fabrication of nanopore arrays on
freestanding SiN and graphene membranes based on electron-beam lithography and …