C3 glomerulopathy—understanding a rare complement-driven renal disease
The C3 glomerulopathies are a group of rare kidney diseases characterized by complement
dysregulation occurring in the fluid phase and in the glomerular microenvironment, which …
dysregulation occurring in the fluid phase and in the glomerular microenvironment, which …
Complement regulators and inhibitory proteins
PF Zipfel, C Skerka - Nature Reviews Immunology, 2009 - nature.com
The complement system is important for cellular integrity and tissue homeostasis.
Complement activation mediates the removal of microorganisms and the clearance of …
Complement activation mediates the removal of microorganisms and the clearance of …
Membranoproliferative glomerulonephritis—a new look at an old entity
S Sethi, FC Fervenza - New England Journal of Medicine, 2012 - Mass Medical Soc
This review discusses the causes, pathogenesis, and clinical management of
membranoproliferative glomerulonephritis, which accounts for 7 to 10% of biopsy-confirmed …
membranoproliferative glomerulonephritis, which accounts for 7 to 10% of biopsy-confirmed …
Mechanisms of haemolysis-induced kidney injury
K Van Avondt, E Nur, S Zeerleder - Nature Reviews Nephrology, 2019 - nature.com
Intravascular haemolysis is a fundamental feature of chronic hereditary and acquired
haemolytic anaemias, including those associated with haemoglobinopathies, complement …
haemolytic anaemias, including those associated with haemoglobinopathies, complement …
Complement control protein factor H: the good, the bad, and the inadequate
The complement system is an essential component of the innate immune system that
participates in elimination of pathogens and altered host cells and comprises an essential …
participates in elimination of pathogens and altered host cells and comprises an essential …
[HTML][HTML] C3 glomerulonephritis: clinicopathological findings, complement abnormalities, glomerular proteomic profile, treatment, and follow-up
S Sethi, FC Fervenza, Y Zhang, L Zand, JA Vrana… - Kidney international, 2012 - Elsevier
C3 glomerulonephritis (C3GN) is a recently described disorder that typically results from
abnormalities in the alternative pathway (AP) of complement. Here, we describe the clinical …
abnormalities in the alternative pathway (AP) of complement. Here, we describe the clinical …
KDOQI US commentary on the 2012 KDIGO clinical practice guideline for glomerulonephritis
Glomerulonephritis (GN) is an important cause of morbidity and mortality in patients of all
ages throughout the world. Because these disorders are relatively rare, it is difficult to …
ages throughout the world. Because these disorders are relatively rare, it is difficult to …
The role of complement in kidney disease
V Petr, JM Thurman - Nature Reviews Nephrology, 2023 - nature.com
The complement cascade comprises soluble and cell surface proteins and is an important
arm of the innate immune system. Once activated, the complement system rapidly generates …
arm of the innate immune system. Once activated, the complement system rapidly generates …
C3 glomerulopathy: a new classification
F Fakhouri, V Frémeaux-Bacchi, LH Noël… - Nature Reviews …, 2010 - nature.com
Several distinct pathological patterns of glomerular inflammation are associated with
abnormal regulation of the complement system, specifically, with dysregulation of the …
abnormal regulation of the complement system, specifically, with dysregulation of the …
Complement factor H in host defense and immune evasion
Complement is the major humoral component of the innate immune system. It recognizes
pathogen-and damage-associated molecular patterns, and initiates the immune response in …
pathogen-and damage-associated molecular patterns, and initiates the immune response in …