The C3 glomerulopathies are a group of rare kidney diseases characterized by complement
dysregulation occurring in the fluid phase and in the glomerular microenvironment, which …

The complement cascade comprises soluble and cell surface proteins and is an important
arm of the innate immune system. Once activated, the complement system rapidly generates …

The complement system is important for cellular integrity and tissue homeostasis.
Complement activation mediates the removal of microorganisms and the clearance of …

Intravascular haemolysis is a fundamental feature of chronic hereditary and acquired
haemolytic anaemias, including those associated with haemoglobinopathies, complement …

This review discusses the causes, pathogenesis, and clinical management of
membranoproliferative glomerulonephritis, which accounts for 7 to 10% of biopsy-confirmed …

Introduction Complement 3 glomerulopathy (C3G) is a rare inflammatory kidney disease
mediated by dysregulation of the alternative complement pathway. No targeted therapy …

The complement system is an essential component of the innate immune system that
participates in elimination of pathogens and altered host cells and comprises an essential …

Complement is the major humoral component of the innate immune system. It recognizes
pathogen-and damage-associated molecular patterns, and initiates the immune response in …

C3 glomerulonephritis (C3GN) is a recently described disorder that typically results from
abnormalities in the alternative pathway (AP) of complement. Here, we describe the clinical …

Several distinct pathological patterns of glomerular inflammation are associated with
abnormal regulation of the complement system, specifically, with dysregulation of the …