The past 25 years of genomics research first revealed which genes are encoded by the
human genome and then a detailed catalogue of human genome variation associated with …

Epigenome editing has rapidly evolved in recent years, with diverse applications that
include elucidating gene regulation mechanisms, annotating coding and noncoding …

The CRISPR genome editing technology has revolutionized the way gene function is
studied. Genome editing can be achieved in single genes or for thousands of genes …

Regulation of gene expression is a complex but highly guided process. While genomic
technologies and computational approaches have allowed high-throughput map** of cis …

The ENCODE Consortium's efforts to annotate noncoding cis-regulatory elements (CREs)
have advanced our understanding of gene regulatory landscapes. Pooled, noncoding …

Genetic variations (including substitutions, insertions, and deletions) exert a profound
influence on DNA sequences. These variations are systematically classified as synonymous …

Enhancers orchestrate gene expression programs that drive multicellular development and
lineage commitment. Thus, genetic variants at enhancers are thought to contribute to …

CRISPR epigenomic editing technologies enable functional interrogation of non-coding
elements. However, current computational methods for guide RNA (gRNA) design do not …