Despite the success of targeted therapies in cancer treatment, therapy-induced resistance
remains a major obstacle to a complete cure. Tumor cells evade treatments and relapse via …

The nature of fluid dynamics within the brain parenchyma is a focus of intensive research. Of
particular relevance is its participation in diseases associated with protein accumulation and …

Neuroimmunology, albeit a relatively established discipline, has recently sparked numerous
exciting findings on microglia, the resident macrophages of the central nervous system …

The recent discovery of meningeal lymphatic vessels (LVs) has raised interest in their
possible involvement in neuropathological processes, yet little is known about their …

The recent discovery of lymphatic vessels (LVs) in the dura mater, the outermost layer of
meninges around the central nervous system (CNS), has opened a possibility for the …

The belief that the vertebrate brain functions normally without classical lymphatic drainage
vessels has been held for many decades. On the contrary, new findings show that functional …

The blood–brain barrier (BBB) restricts free access of molecules between the blood and the
brain and is essential for regulating the neural microenvironment. Here, we describe how …

Recent discoveries of novel functions and diverse origins of lymphatic vessels have
drastically changed our view of lymphatic vasculature. Traditionally regarded as passive …

There are no conventional lymphatic vessels within the CNS parenchyma, although it has
been hypothesized that lymphatics near the cribriform plate or dura maintain fluid …

Our vasculature plays diverse and critical roles in homeostasis and disease. In recent
decades, the use of zebrafish has driven our understanding of vascular development into …