Depression is one of the most frequent and burdensome non-motor symptoms in
Parkinson's disease (PD), across all stages. Even when its severity is mild, PD depression …

Deep brain stimulation (DBS) of 3 different targets is the most important therapeutic
innovation of the past 30 years for patients with fluctuating Parkinson's disease (PD) …

Objective Real‐life observational report of clinical efficacy of bilateral subthalamic
stimulation (STN‐DBS), apomorphine (APO), and intrajejunal levodopa infusion (IJLI) on …

Deep brain stimulation of the subthalamic nucleus is an effective and established therapy for
patients with advanced Parkinson's disease improving quality of life, motor symptoms and …

Deep brain stimulation (DBS) depends on precise delivery of electrical current to target
tissues. However, the specific brain structures responsible for best outcome are still debated …

Importance Deep brain stimulation of the subthalamic nucleus (STN-DBS) improves quality
of life (QOL) in patients with advanced Parkinson disease (PD). However, controlled studies …

Apathy is commonly defined as a loss of motivation leading to a reduction in goal-directed
behaviors. This multidimensional syndrome, which includes cognitive, emotional and …

Objective Subthalamic nucleus deep brain stimulation (STN‐DBS) in Parkinson's disease
(PD) not only stimulates focal target structures but also affects distributed brain networks …

The Subthalamic Nucleus (STh) is an oval-shaped diencephalic structure located ventrally
to the thalamus, playing a fundamental role in the circuitry of the basal ganglia. In addition to …

Postoperative apathy is a frequent symptom in Parkinson's disease patients who have
undergone bilateral deep brain stimulation of the subthalamic nucleus. Two main …