Infections with antimicrobial-resistant (AMR) bacteria pose an increasing threat to the ability
to perform surgical procedures, organ transplantation, and treat cancer among many other …

Recurrent vulvovaginal candidiasis (RVVC) is one of the most prevalent fungal infections in
humans, especially in develo** countries; however, it is underestimated and regarded as …

Background There have been reports of increasing azole resistance in Candida tropicalis,
especially in the Asia-Pacific region. Here we report on the epidemiology and antifungal …

Sterol 14α-demethylase catalyzes lanosterol hydroxylation, which is one of the key reactions
in the biosynthetic pathway of sterols. There is only one sterol 14α-demethylases gene …

The silent pandemic caused by antimicrobial resistance (AMR) requires innovative
therapeutic approaches. Human monoclonal antibodies (mAbs), which are among the most …

The synergistic combinations of drugs are promising strategies to boost the effectiveness of
current antifungals and thus prevent the emergence of resistance. In this work, we show that …

The increased resistance of Candida albicans to conventional antifungal drugs poses a
huge challenge to the clinical treatment of this infection. In recent years, combination …

Talaromyces (Penicillium) marneffei (T. marneffei) is a thermally dimorphic fungus that can
cause opportunistic systemic mycoses. Our previous study demonstrated that concomitant …

Carbapenem-resistant Klebsiella pneumoniae (CRKP) is emerging as an imminent threat to
worldwide public health because of its high level of antimicrobial resistance, which can …

Antimicrobial resistance is a silent yet deadly threat to public health that requires immediate
action at the global scale, calling for preparedness to rapidly develop novel therapeutic …