Functional precision medicine is a strategy whereby live tumor cells from affected individuals
are directly perturbed with drugs to provide immediately translatable, personalized …

The loss of vital cells within healthy tissues contributes to the development, progression and
treatment outcomes of many human disorders, including neurological and infectious …

Despite the success of PD-1 blockade in melanoma and other cancers, effective treatment
strategies to overcome resistance to cancer immunotherapy are lacking,. Here we identify …

Children with rare, relapsed or refractory cancers often face limited treatment options, and
few predictive biomarkers are available that can enable personalized treatment …

Deregulation of the BCL-2 family interaction network ensures cancer resistance to apoptosis
and is a major challenge to current treatments. Cancer cells commonly evade apoptosis …

Personalized medicine aims to match the right drug with the right patient by using specific
features of the individual patient's tumor. However, current strategies of personalized …

Treatment-persistent residual tumors impede curative cancer therapy. To understand this
cancer cell state we generated models of treatment persistence that simulate the residual …

Proteins of the B-cell lymphoma-2 (BCL-2) family control the intrinsic apoptosis pathway.
The pro-apoptotic BCL-2 proteins BAX and BAK can commit a cell to its programmed death …

Pyroptosis, a form of programmed cell death, has garnered increasing attention as it relates
to innate immunity and diseases. The discovery of caspase-1/3/4/5/8/11 function in sensing …

Apoptotic cell death is widely considered a positive process that both prevents and treats
cancer. Although undoubtedly having a beneficial role, paradoxically, apoptosis can also …