The roles of the hippocampus and prefrontal cortex (PFC) in memory processing—
individually or in concert—are a major topic of interest in memory research. These brain …

Scientists have long sought to characterize the pathophysiologic basis of schizophrenia and
develop biomarkers that could identify the illness. Extensive postmortem and in vivo …

The glutamate and dopamine hypotheses are leading theories of the pathoaetiology of
schizophrenia. Both were initially based on indirect evidence from pharmacological studies …

Episodic memory deficits are consistently documented as a core aspect of cognitive
dysfunction in schizophrenia patients, present from the onset of the illness and strongly …

Successful behavior requires actively acquiring and representing information about the
environment and people, and manipulating and using those acquired representations …

The hippocampal formation has been implicated in a growing number of disorders, from
Alzheimer's disease and cognitive ageing to schizophrenia and depression. How can the …

The hippocampus in schizophrenia is characterized by both hypermetabolism and reduced
size. It remains unknown whether these abnormalities are mechanistically linked. Here we …

Dopamine (DA) and glutamate neurotransmission are strongly implicated in schizophrenia
pathophysiology. While most studies focus on contributions of neurons that release only DA …

Positron emission tomography (PET) and functional magnetic resonance imaging (fMRI)
have been extensively used to explore the functional neuroanatomy of cognitive functions …

To date, there has been little investigation of the neurobiological basis of emotion
processing abnormalities in psychiatric populations. We have previously discussed two …