Triglyceride-rich lipoproteins and high-density lipoprotein cholesterol in patients at high risk of cardiovascular disease: evidence and guidance for management
Even at low-density lipoprotein cholesterol (LDL-C) goal, patients with cardiometabolic
abnormalities remain at high risk of cardiovascular events. This paper aims (i) to critically …
abnormalities remain at high risk of cardiovascular events. This paper aims (i) to critically …
High-density lipoproteins: nature's multifunctional nanoparticles
High-density lipoproteins (HDL) are endogenous nanoparticles involved in the transport and
metabolism of cholesterol, phospholipids, and triglycerides. HDL is well-known as the …
metabolism of cholesterol, phospholipids, and triglycerides. HDL is well-known as the …
Prevalence of and risk factors for diabetic peripheral neuropathy in youth with type 1 and type 2 diabetes: SEARCH for diabetes in youth study
OBJECTIVE We assessed the prevalence of and risk factors for diabetic peripheral
neuropathy (DPN) in youth with type 1 diabetes (T1D) and type 2 diabetes (T2D) enrolled in …
neuropathy (DPN) in youth with type 1 diabetes (T1D) and type 2 diabetes (T2D) enrolled in …
High-density lipoproteins during sepsis: from bench to bedside
High-density lipoproteins (HDLs) represent a family of particle characterized by the
presence of apolipoprotein AI (apoA-I) and by their ability to transport cholesterol from …
presence of apolipoprotein AI (apoA-I) and by their ability to transport cholesterol from …
HDL and cardiovascular disease: atherogenic and atheroprotective mechanisms
The lipoprotein HDL has two important roles: first, it promotes reverse cholesterol transport,
and second, it modulates inflammation. Epidemiological studies show that HDL-cholesterol …
and second, it modulates inflammation. Epidemiological studies show that HDL-cholesterol …
HDL-targeted therapies: progress, failures and future
Since the discovery in the 1970s that plasma levels of high-density lipoprotein cholesterol
(HDL-C) are inversely associated with cardiovascular outcome, it has been postulated that …
(HDL-C) are inversely associated with cardiovascular outcome, it has been postulated that …
ApoE regulates hematopoietic stem cell proliferation, monocytosis, and monocyte accumulation in atherosclerotic lesions in mice
AJ Murphy, M Akhtari, S Tolani, T Pagler… - The Journal of …, 2011 - Am Soc Clin Investig
Leukocytosis is associated with increased cardiovascular disease risk in humans and
develops in hypercholesterolemic atherosclerotic animal models. Leukocytosis is associated …
develops in hypercholesterolemic atherosclerotic animal models. Leukocytosis is associated …
HDL function and atherosclerosis: reactive dicarbonyls as promising targets of therapy
MRF Linton, PG Yancey, H Tao, SS Davies - Circulation research, 2023 - Am Heart Assoc
Epidemiologic studies detected an inverse relationship between HDL (high-density
lipoprotein) cholesterol (HDL-C) levels and atherosclerotic cardiovascular disease …
lipoprotein) cholesterol (HDL-C) levels and atherosclerotic cardiovascular disease …
The emerging role of HDL in glucose metabolism
A low plasma level of HDL cholesterol is an atherosclerotic risk factor; however, emerging
evidence suggests that low HDL levels might also contribute to the pathophysiology of type …
evidence suggests that low HDL levels might also contribute to the pathophysiology of type …
Anti-inflammatory effects of HDL (high-density lipoprotein) in macrophages predominate over proinflammatory effects in atherosclerotic plaques
Objective: HDL (high-density lipoprotein) infusion reduces atherosclerosis in animal models
and is being evaluated as a treatment in humans. Studies have shown either anti-or …
and is being evaluated as a treatment in humans. Studies have shown either anti-or …