The skeleton is a highly innervated organ in which nerve fibers interact with various skeletal
cells. Peripheral nerve endings release neurogenic factors and sense skeletal signals …

Skeletal tissue is highly innervated. Although different types of nerves have been recently
identified in the bone, the crosstalk between bone and nerves remains unclear. In this …

The chronic use of glucocorticoids decreases bone mass and quality and increases bone-
marrow adiposity, but the underlying mechanisms remain unclear. Here, we show that bone …

Genetics in model organisms has progressively broken down walls that previously
separated different disciplines of biology. One example of this holistic evolution is the …

For the past two decades, the function of intrabony nerves on bone has been a subject of
intense research, while the function of bone on intrabony nerves is still hidden in the corner …

The interoception maintains proper physiological conditions and metabolic homeostasis by
releasing regulatory signals after perceving changes in the internal state of the organism …

The mechanisms that coordinate the shift from joint homeostasis to osteoarthritis (OA)
remain unknown. No pharmacological intervention can currently prevent the progression of …

Recent studies have determined that the nervous system can sense and respond to signals
from skeletal tissue, a process known as skeletal interoception, which is crucial for …

The homeostasis of bone microenvironment is the foundation of bone health and comprises
2 concerted events: bone formation by osteoblasts and bone resorption by osteoclasts. In …

Mesenchymal stem cells (MSCs) reside in microenvironments, referred to as niches, which
provide structural support and molecular signals. Sensory nerves are niche components in …