[HTML][HTML] Iron mediated toxicity and programmed cell death: A review and a re-examination of existing paradigms

R Eid, NTT Arab, MT Greenwood - … et Biophysica Acta (BBA)-Molecular Cell …, 2017 - Elsevier
Iron is an essential micronutrient that is problematic for biological systems since it is toxic as
it generates free radicals by interconverting between ferrous (Fe 2+) and ferric (Fe 3+) forms …

[HTML][HTML] Copper metabolism and its role in diabetic complications: A review

D Jia, L Liu, W Liu, J Li, X Jiang, Y **n - Pharmacological Research, 2024 - Elsevier
Disturbances in copper (Cu) homeostasis have been observed in diabetes and associated
complications. Cu is an essential micronutrient that plays important roles in various …

Pathologically high intraocular pressure disturbs normal iron homeostasis and leads to retinal ganglion cell ferroptosis in glaucoma

F Yao, J Peng, E Zhang, D Ji, Z Gao, Y Tang… - Cell Death & …, 2023 - nature.com
Glaucoma can result in retinal ganglion cell (RGC) death and permanently damaged vision.
Pathologically high intraocular pressure (ph-IOP) is the leading cause of damaged vision …

The many “faces” of copper in medicine and treatment

A Hordyjewska, Ł Popiołek, J Kocot - Biometals, 2014 - Springer
Copper (Cu) is an essential microelement found in all living organisms with the unique
ability to adopt two different redox states—in the oxidized (Cu 2+) and reduced (Cu+). It is …

Senescence in the pathogenesis of age-related macular degeneration

J Blasiak - Cellular and Molecular Life Sciences, 2020 - Springer
Age-related macular degeneration (AMD) is a complex eye disease underlined by the death
of photoreceptors and degeneration of retinal pigment epithelium (RPE) and choriocapillaris …

Pyrene-Based Fluorescent Probe for “Off-on-Off” Sequential Detection of Cu2+ and CN with HeLa Cells Imaging

M Shellaiah, P Venkatesan, N Thirumalaivasan, SP Wu… - Chemosensors, 2023 - mdpi.com
The novel pyrene-appended Schiff base probe L with aggregation-induced emissions (AIE)
relevant to an increase in water fractions (0–90%) is synthesized and applied in sequentially …

[HTML][HTML] The age-related eye disease 2 study: micronutrients in the treatment of macular degeneration

A Gorusupudi, K Nelson, PS Bernstein - Advances in Nutrition, 2017 - Elsevier
Age-related macular degeneration (AMD) is one of the leading causes of vision loss in the
elderly. With an increasingly aged population worldwide, the need for the prevention of AMD …

[HTML][HTML] Anthropogenic hyperactivity for natural resources increases heavy metals concentrations in the environment: Toxicity of healthy food and cancer risks …

DJ Machate - Journal of Trace Elements and Minerals, 2023 - Elsevier
Anthropogenic hyperactivities for natural resources cause increasing concentrations of
heavy metals and metalloids in the environment, which hazard human health. This review …

[HTML][HTML] Effects of copper exposure on oxidative stress, apoptosis, endoplasmic reticulum stress, autophagy and immune response in different tissues of Chinese …

W Feng, S Su, C Song, F Yu, J Zhou, J Li, R Jia, P Xu… - Antioxidants, 2022 - mdpi.com
High concentrations of copper (Cu2+) pose a great threat to aquatic animals. However, the
mechanisms underlying the response of crustaceans to Cu2+ exposure have not been well …

Temporal single-cell atlas of non-neuronal retinal cells reveals dynamic, coordinated multicellular responses to central nervous system injury

I Benhar, J Ding, W Yan, IE Whitney, A Jacobi… - Nature …, 2023 - nature.com
Non-neuronal cells are key to the complex cellular interplay that follows central nervous
system insult. To understand this interplay, we generated a single-cell atlas of immune, glial …