Mechanical state transitions in the regulation of tissue form and function

Y Mao, SA Wickström - Nature Reviews Molecular Cell Biology, 2024 - nature.com
From embryonic development, postnatal growth and adult homeostasis to reparative and
disease states, cells and tissues undergo constant changes in genome activity, cell fate …

Physics of microswimmers—single particle motion and collective behavior: a review

J Elgeti, RG Winkler, G Gompper - Reports on progress in …, 2015 - iopscience.iop.org
Locomotion and transport of microorganisms in fluids is an essential aspect of life. Search
for food, orientation toward light, spreading of off-spring, and the formation of colonies are …

Cell–cell adhesion and 3D matrix confinement determine jamming transitions in breast cancer invasion

O Ilina, PG Gritsenko, S Syga, J Lippoldt… - Nature cell …, 2020 - nature.com
Plasticity of cancer invasion and metastasis depends on the ability of cancer cells to switch
between collective and single-cell dissemination, controlled by cadherin-mediated cell–cell …

A fluid-to-solid jamming transition underlies vertebrate body axis elongation

A Mongera, P Rowghanian, HJ Gustafson, E Shelton… - Nature, 2018 - nature.com
Just as in clay moulding or glass blowing, physically sculpting biological structures requires
the constituent material to locally flow like a fluid while maintaining overall mechanical …

Motility-driven glass and jamming transitions in biological tissues

D Bi, X Yang, MC Marchetti, ML Manning - Physical Review X, 2016 - APS
Cell motion inside dense tissues governs many biological processes, including embryonic
development and cancer metastasis, and recent experiments suggest that these tissues …

Unjamming and cell shape in the asthmatic airway epithelium

JA Park, JH Kim, D Bi, JA Mitchel, NT Qazvini… - Nature materials, 2015 - nature.com
From coffee beans flowing in a chute to cells remodelling in a living tissue, a wide variety of
close-packed collective systems—both inert and living—have the potential to jam. The …

Self-enhanced mobility enables vortex pattern formation in living matter

H Xu, Y Wu - Nature, 2024 - nature.com
Ranging from subcellular organelle biogenesis to embryo development, the formation of self-
organized structures is a hallmark of living systems. Whereas the emergence of ordered …

A density-independent rigidity transition in biological tissues

D Bi, JH Lopez, JM Schwarz, ML Manning - Nature Physics, 2015 - nature.com
Cell migration is important in many biological processes, including embryonic development,
cancer metastasis and wound healing. In these tissues, a cell's motion is often strongly …

Mechanisms and impact of altered tumour mechanics

H Mohammadi, E Sahai - Nature cell biology, 2018 - nature.com
The physical characteristics of tumours are intricately linked to the tumour phenotype and
difficulties during treatment. Many factors contribute to the increased stiffness of tumours; …

Hydrodynamics of soft active matter

MC Marchetti, JF Joanny, S Ramaswamy… - Reviews of modern …, 2013 - APS
This review summarizes theoretical progress in the field of active matter, placing it in the
context of recent experiments. This approach offers a unified framework for the mechanical …