Advances in the science and treatment of alcohol use disorder

K Witkiewitz, RZ Litten, L Leggio - Science advances, 2019 - science.org
Alcohol is a major contributor to global disease and a leading cause of preventable death,
causing approximately 88,000 deaths annually in the United States alone. Alcohol use …

DSM-5 criteria for substance use disorders: recommendations and rationale

DS Hasin, CP O'brien, M Auriacombe… - American Journal of …, 2013 - Am Psychiatric Assoc
Since DSM-IV was published in 1994, its approach to substance use disorders has come
under scrutiny. Strengths were identified (notably, reliability and validity of dependence), but …

Multi-ancestry study of the genetics of problematic alcohol use in over 1 million individuals

H Zhou, RL Kember, JD Deak, H Xu, S Toikumo… - Nature Medicine, 2023 - nature.com
Problematic alcohol use (PAU), a trait that combines alcohol use disorder and alcohol-
related problems assessed with a questionnaire, is a leading cause of death and morbidity …

The American Psychiatric Association practice guideline for the pharmacological treatment of patients with alcohol use disorder

VI Reus, LJ Fochtmann, O Bukstein… - American Journal of …, 2018 - Am Psychiatric Assoc
The goal of this guideline1 is to improve the quality of care and treatment outcomes for
patients with alcohol use disorder (AUD), as defined by DSM-5 (American Psychiatric …

The behavioral economics of substance use disorders: reinforcement pathologies and their repair

WK Bickel, MW Johnson, MN Koffarnus… - Annual review of …, 2014 - annualreviews.org
The field of behavioral economics has made important inroads into the understanding of
substance use disorders through the concept of reinforcer pathology. Reinforcer pathology …

Addictions neuroclinical assessment: a neuroscience-based framework for addictive disorders

LE Kwako, R Momenan, RZ Litten, GF Koob… - Biological …, 2016 - Elsevier
This article proposes a heuristic framework for the Addictions Neuroclinical Assessment that
incorporates key functional domains derived from the neurocircuitry of addiction. We review …

[LLIBRE][B] Behavioral genetics

R Plomin - 2008 - books.google.com
Behavioral Genetics, Fifth Edition provides an engaging and clear overview of human and
animal behavioral genetics that is designed to introduce students in the behavioral …

Opioid antagonists for alcohol dependence

S Roesner, A Hackl‐Herrwerth… - Cochrane database …, 2010 - cochranelibrary.com
Background Alcohol dependence belongs to the globally leading health risk factors.
Therapeutic success of psychosocial programs for relapse prevention is moderate and could …

Alcoholism: a systems approach from molecular physiology to addictive behavior

R Spanagel - Physiological reviews, 2009 - journals.physiology.org
Alcohol consumption is an integral part of daily life in many societies. The benefits
associated with the production, sale, and use of alcoholic beverages come at an enormous …

The genetic basis of addictive disorders

F Ducci, D Goldman - Psychiatric Clinics, 2012 - psych.theclinics.com
• Genetic and environmental influences modulating risk of substance use disorders change
developmentally and across the lifespan.• Genes involved in vulnerability to addictions …