Sleep and memory: The impact of sleep deprivation on transcription, translational control, and protein synthesis in the brain

LC Lyons, Y Vanrobaeys, T Abel - Journal of neurochemistry, 2023 - Wiley Online Library
In countries around the world, sleep deprivation represents a widespread problem affecting
school‐age children, teenagers, and adults. Acute sleep deprivation and more chronic sleep …

Unveiling the role of histone deacetylases in neurological diseases: focus on epilepsy

DF Cao, XY Zhou, Q Guo, MY **ang, MH Bao… - Biomarker …, 2024 - Springer
Epilepsy remains a prevalent chronic neurological disease that is featured by aberrant,
recurrent and hypersynchronous discharge of neurons and poses a great challenge to …

Incubation of methamphetamine craving in punishment-resistant individuals is associated with activation of specific gene networks in the rat dorsal striatum

AP Daiwile, MT McCoy, B Ladenheim… - Molecular …, 2024 - nature.com
Methamphetamine use disorder (MUD) is characterized by loss of control over compulsive
drug use. Here, we used a self-administration (SA) model to investigate transcriptional …

Gut microbiota regulates hepatic ischemia–reperfusion injury‐induced cognitive dysfunction via the HDAC2‐ACSS2 axis in mice

Y Liu, Z Li, T Sun, Z Li, A Manyande… - CNS Neuroscience & …, 2024 - Wiley Online Library
Aims Hepatic ischemia–reperfusion injury (HIRI) resulting from hepatic inflow occlusion,
which is a common procedure in liver surgery is inevitable. Previous research has confirmed …

The impact of sex on memory during aging and Alzheimer's disease progression: Epigenetic mechanisms

SB Scheinman, H Dong - Journal of Alzheimer's Disease, 2024 - journals.sagepub.com
Alzheimer's disease (AD) is a leading cause of dementia, disability, and death in the elderly.
While the etiology of AD is unknown, there are several established risk factors for the …

Elucidation of the working principle of a gene-directed caged HDAC inhibitor with cell-type selectivity

K Sakamoto, A Hirano, R Hidaka, AZ Suzuki… - Chemical …, 2022 - pubs.rsc.org
Histone deacetylases (HDACs) play crucial roles in the epigenetic regulation of gene
expression. Here, we report CM-Bhc-SAHA, a novel caged HDAC inhibitor, genetically …

Computational insights in repurposing a cardiovascular drug for Alzheimer's disease: the role of aromatic amino acids in stabilizing the drug through π–π stacking …

SME Rubavathy, M Prakash - Physical Chemistry Chemical Physics, 2025 - pubs.rsc.org
Alzheimer's disease (AD) is a neurological condition that worsens over time and causes
linguistic difficulties, cognitive decline, and memory loss. Since AD is a complicated …

Exploration of novel hydroxamate zinc binding group inhibitors against HDAC-1-3 enzymes by AI-based virtual screening: atomistic insights from steered molecular …

SM Esther Rubavathy, V Rajapandian… - Journal of Biomolecular …, 2024 - Taylor & Francis
Overexpression of histone deacetylase (HDAC) enzymes is linked to a wide variety of
illnesses, including malignancies and neurological disorders, which makes HDAC inhibitors …

Oncogenic Gene CNOT7 Promotes Progression and Induces Poor Prognosis of Glioma

F Lu, X Jiang, K Lin, P Zheng, S Wu, G Zeng… - Molecular …, 2024 - Springer
Glioma is the most common malignant brain tumor in the central nervous system with the
poor prognosis of patients. The CNOT7 (CCR4-NOT Transcription Complex Subunit 7) is an …

Isoflurane impairs GluN2B‐containing NMDA receptors trafficking and cognition via decreasing histone acetylation and EphB2 expression in aged hippocampal …

JR Hao, QM Hu, X Yang, P Wei… - Basic & Clinical …, 2023 - Wiley Online Library
Perioperative neurocognitive disorders (PND) is a common complication that occurs among
elderly patients in the perioperative course. Current clinical evidence has shown that …