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Sleep and memory: The impact of sleep deprivation on transcription, translational control, and protein synthesis in the brain
In countries around the world, sleep deprivation represents a widespread problem affecting
school‐age children, teenagers, and adults. Acute sleep deprivation and more chronic sleep …
school‐age children, teenagers, and adults. Acute sleep deprivation and more chronic sleep …
Unveiling the role of histone deacetylases in neurological diseases: focus on epilepsy
DF Cao, XY Zhou, Q Guo, MY **ang, MH Bao… - Biomarker …, 2024 - Springer
Epilepsy remains a prevalent chronic neurological disease that is featured by aberrant,
recurrent and hypersynchronous discharge of neurons and poses a great challenge to …
recurrent and hypersynchronous discharge of neurons and poses a great challenge to …
Incubation of methamphetamine craving in punishment-resistant individuals is associated with activation of specific gene networks in the rat dorsal striatum
Methamphetamine use disorder (MUD) is characterized by loss of control over compulsive
drug use. Here, we used a self-administration (SA) model to investigate transcriptional …
drug use. Here, we used a self-administration (SA) model to investigate transcriptional …
Gut microbiota regulates hepatic ischemia–reperfusion injury‐induced cognitive dysfunction via the HDAC2‐ACSS2 axis in mice
Y Liu, Z Li, T Sun, Z Li, A Manyande… - CNS Neuroscience & …, 2024 - Wiley Online Library
Aims Hepatic ischemia–reperfusion injury (HIRI) resulting from hepatic inflow occlusion,
which is a common procedure in liver surgery is inevitable. Previous research has confirmed …
which is a common procedure in liver surgery is inevitable. Previous research has confirmed …
The impact of sex on memory during aging and Alzheimer's disease progression: Epigenetic mechanisms
SB Scheinman, H Dong - Journal of Alzheimer's Disease, 2024 - journals.sagepub.com
Alzheimer's disease (AD) is a leading cause of dementia, disability, and death in the elderly.
While the etiology of AD is unknown, there are several established risk factors for the …
While the etiology of AD is unknown, there are several established risk factors for the …
Elucidation of the working principle of a gene-directed caged HDAC inhibitor with cell-type selectivity
K Sakamoto, A Hirano, R Hidaka, AZ Suzuki… - Chemical …, 2022 - pubs.rsc.org
Histone deacetylases (HDACs) play crucial roles in the epigenetic regulation of gene
expression. Here, we report CM-Bhc-SAHA, a novel caged HDAC inhibitor, genetically …
expression. Here, we report CM-Bhc-SAHA, a novel caged HDAC inhibitor, genetically …
Computational insights in repurposing a cardiovascular drug for Alzheimer's disease: the role of aromatic amino acids in stabilizing the drug through π–π stacking …
Alzheimer's disease (AD) is a neurological condition that worsens over time and causes
linguistic difficulties, cognitive decline, and memory loss. Since AD is a complicated …
linguistic difficulties, cognitive decline, and memory loss. Since AD is a complicated …
Exploration of novel hydroxamate zinc binding group inhibitors against HDAC-1-3 enzymes by AI-based virtual screening: atomistic insights from steered molecular …
Overexpression of histone deacetylase (HDAC) enzymes is linked to a wide variety of
illnesses, including malignancies and neurological disorders, which makes HDAC inhibitors …
illnesses, including malignancies and neurological disorders, which makes HDAC inhibitors …
Oncogenic Gene CNOT7 Promotes Progression and Induces Poor Prognosis of Glioma
F Lu, X Jiang, K Lin, P Zheng, S Wu, G Zeng… - Molecular …, 2024 - Springer
Glioma is the most common malignant brain tumor in the central nervous system with the
poor prognosis of patients. The CNOT7 (CCR4-NOT Transcription Complex Subunit 7) is an …
poor prognosis of patients. The CNOT7 (CCR4-NOT Transcription Complex Subunit 7) is an …
Isoflurane impairs GluN2B‐containing NMDA receptors trafficking and cognition via decreasing histone acetylation and EphB2 expression in aged hippocampal …
JR Hao, QM Hu, X Yang, P Wei… - Basic & Clinical …, 2023 - Wiley Online Library
Perioperative neurocognitive disorders (PND) is a common complication that occurs among
elderly patients in the perioperative course. Current clinical evidence has shown that …
elderly patients in the perioperative course. Current clinical evidence has shown that …