Evolution of host innate defence: insights from Caenorhabditis elegans and primitive invertebrates
The genetically tractable model organism Caenorhabditis elegans was first used to model
bacterial virulence in vivo a decade ago. Since then, great strides have been made in …
bacterial virulence in vivo a decade ago. Since then, great strides have been made in …
Death associated protein kinase 1 (DAPK1): a regulator of apoptosis and autophagy
Death-Associated Protein Kinase 1 (DAPK1) belongs to a family of five serine/threonine
(Ser/Thr) kinases that possess tumor suppressive function and also mediate a wide range of …
(Ser/Thr) kinases that possess tumor suppressive function and also mediate a wide range of …
Dapk1 improves inflammation, oxidative stress and autophagy in LPS-induced acute lung injury via p38MAPK/NF-κB signaling pathway
T Li, YN Wu, H Wang, JY Ma, SS Zhai, J Duan - Molecular immunology, 2020 - Elsevier
Objective To investigate the impact of death-associated protein kinase 1 (Dapk1) on
lipopolysaccharide (LPS)-induced acute lung injury (ALI) via p38MAPK/NF-κB pathway …
lipopolysaccharide (LPS)-induced acute lung injury (ALI) via p38MAPK/NF-κB pathway …
Nanoscale patterning of collagens in C. elegans apical extracellular matrix
JRG Adams, M Pooranachithra, EM Jyo… - Nature …, 2023 - nature.com
Apical extracellular matrices (aECMs) are complex extracellular compartments that form
important interfaces between animals and their environment. In the adult C. elegans cuticle …
important interfaces between animals and their environment. In the adult C. elegans cuticle …
MAPK signaling promotes axonal degeneration by speeding the turnover of the axonal maintenance factor NMNAT2
Injury-induced (Wallerian) axonal degeneration is regulated via the opposing actions of pro-
degenerative factors such as SARM1 and a MAPK signal and pro-survival factors, the most …
degenerative factors such as SARM1 and a MAPK signal and pro-survival factors, the most …
[PDF][PDF] Signaling in the innate immune response
DH Kim - 2015 - dspace.mit.edu
The maintenance of cellular and organismal homeostasis in the face of changes in the
environment is essential for survival. Pathogenic microorganisms represent one type of …
environment is essential for survival. Pathogenic microorganisms represent one type of …
[HTML][HTML] A Gαq-Ca2+ signaling pathway promotes actin-mediated epidermal wound closure in C. elegans
Background Repair of skin wounds is essential for animals to survive in a harsh
environment, yet the signaling pathways initiating wound repair in vivo remain little …
environment, yet the signaling pathways initiating wound repair in vivo remain little …
Innate immunity in C. elegans
In its natural habitat, C. elegans encounters a wide variety of microbes, including food,
commensals and pathogens. To be able to survive long enough to reproduce, C. elegans …
commensals and pathogens. To be able to survive long enough to reproduce, C. elegans …
A Damage Sensor Associated with the Cuticle Coordinates Three Core Environmental Stress Responses in Caenorhabditis elegans
Although extracellular matrices function as protective barriers to many types of
environmental insult, their role in sensing stress and regulating adaptive gene induction …
environmental insult, their role in sensing stress and regulating adaptive gene induction …
Innate immunity in C. elegans
I Engelmann, N Pujol - Adv Exp Med Biol, 2010 - Springer
The nematodeCaenorhabditis elegansis proving to be a powerful invertebrate model to
study host-pathogen interactions. In common with other invertebrates, C. elegans relies …
study host-pathogen interactions. In common with other invertebrates, C. elegans relies …