Solution-phase hydrogen/deuterium exchange (HDX) coupled to mass spectrometry (MS) is
a widespread tool for structural analysis across academia and the biopharmaceutical …

Simple Summary The PI3K/AKT pathway is one of the most important signaling nodes in
cancer. While class I PI3K roles in cancer are well known, class II and III functions in …

Abstract Phosphoinositide 3-kinase (PI3K) beta (PI3Kβ) is functionally unique in the ability to
integrate signals derived from receptor tyrosine kinases (RTKs), G-protein coupled …

PI3Ks are important lipid kinases that produce phosphoinositides phosphorylated in position
3 of the inositol ring. There are three classes of PI3Ks: class I PI3Ks produce PIP3 at plasma …

Macropinocytosis is an actin-dependent but clathrin-independent endocytic process by
which cells nonselectively take up large aliquots of extracellular material. Macropinocytosis …

Abstract Background Circular dorsal ruffles (CDRs) are rounded membrane ruffles induced
on the dorsal surfaces of cells stimulated by growth factors (GF). They can serve as signal …

Abstract The phosphoinositide 3-kinase (PI3K) superfamily includes lipid kinases (PI3Ks
and type III PI4Ks) and a group of PI3K-like Ser/Thr protein kinases (PIKKs: mTOR, ATM …

The invasion of tumor cells from the primary tumor is mediated by invadopodia, actin-rich
protrusive organelles that secrete matrix metalloproteases and degrade the extracellular …

The core machinery for vesicular membrane trafficking broadly comprises of coat proteins,
RABs, tethering complexes and SNAREs. As cellular membrane traffic modulates key …

Objective* We aimed to explore the mechanism of microRNA-936 (miR-936) targeting G
protein coupled receptor 78 (GPR78) regulating chemoresistance of non-small cell lung …