The role of the extracellular matrix in cancer stemness
S Nallanthighal, JP Heiserman… - Frontiers in cell and …, 2019 - frontiersin.org
As our understanding of cancer cell biology progresses, it has become clear that tumors are
a heterogenous mixture of different cell populations, some of which contain so called …
a heterogenous mixture of different cell populations, some of which contain so called …
Induced pluripotent stem cells and their use in human models of disease and development
The discovery of somatic cell nuclear transfer proved that somatic cells can carry the same
genetic code as the zygote, and that activating parts of this code are sufficient to reprogram …
genetic code as the zygote, and that activating parts of this code are sufficient to reprogram …
Chemically defined generation of human cardiomyocytes
Existing methods for human induced pluripotent stem cell (hiPSC) cardiac differentiation are
efficient but require complex, undefined medium constituents that hinder further elucidation …
efficient but require complex, undefined medium constituents that hinder further elucidation …
Chemically defined conditions for human iPSC derivation and culture
We re-examine the individual components for human embryonic stem cell (ESC) and
induced pluripotent stem cell (iPSC) culture and formulate a cell culture system in which all …
induced pluripotent stem cell (iPSC) culture and formulate a cell culture system in which all …
The extracellular matrix alteration, implication in modulation of drug resistance mechanism: friends or foes?
A Jurj, C Ionescu, I Berindan-Neagoe… - Journal of Experimental & …, 2022 - Springer
The extracellular matrix (ECM) is an important component of the tumor microenvironment
(TME), having several important roles related to the hallmarks of cancer. In cancer, multiple …
(TME), having several important roles related to the hallmarks of cancer. In cancer, multiple …
Long-term self-renewal of human pluripotent stem cells on human recombinant laminin-511
S Rodin, A Domogatskaya, S Ström, EM Hansson… - Nature …, 2010 - nature.com
We describe a system for culturing human embryonic stem (hES) cells and induced
pluripotent stem (iPS) cells on a recombinant form of human laminin-511, a component of …
pluripotent stem (iPS) cells on a recombinant form of human laminin-511, a component of …
Human pluripotent stem cell culture: considerations for maintenance, expansion, and therapeutics
Human pluripotent stem cells (hPSCs) provide powerful resources for application in
regenerative medicine and pharmaceutical development. In the past decade, various …
regenerative medicine and pharmaceutical development. In the past decade, various …
Combinatorial development of biomaterials for clonal growth of human pluripotent stem cells
Both human embryonic stem cells and induced pluripotent stem cells can self-renew
indefinitely in culture; however, present methods to clonally grow them are inefficient and …
indefinitely in culture; however, present methods to clonally grow them are inefficient and …
Mechanics-guided embryonic patterning of neuroectoderm tissue from human pluripotent stem cells
Classic embryological studies have successfully applied genetics and cell biology principles
to understand embryonic development. However, it remains unresolved how mechanics, as …
to understand embryonic development. However, it remains unresolved how mechanics, as …
Synthetic peptide-acrylate surfaces for long-term self-renewal and cardiomyocyte differentiation of human embryonic stem cells
Z Melkoumian, JL Weber, DM Weber, AG Fadeev… - Nature …, 2010 - nature.com
Human embryonic stem cells (hESCs) have two properties of interest for the development of
cell therapies: self-renewal and the potential to differentiate into all major lineages of …
cell therapies: self-renewal and the potential to differentiate into all major lineages of …