Molecular responses to acute exercise and their relevance for adaptations in skeletal muscle to exercise training
Repeated, episodic bouts of skeletal muscle contraction undertaken frequently as structured
exercise training are a potent stimulus for physiological adaptation in many organs …
exercise training are a potent stimulus for physiological adaptation in many organs …
Mechanisms of mechanical overload-induced skeletal muscle hypertrophy: current understanding and future directions
Mechanisms underlying mechanical overload-induced skeletal muscle hypertrophy have
been extensively researched since the landmark report by Morpurgo (1897) of “work …
been extensively researched since the landmark report by Morpurgo (1897) of “work …
Transcriptomic profiling of skeletal muscle adaptations to exercise and inactivity
The molecular mechanisms underlying the response to exercise and inactivity are not fully
understood. We propose an innovative approach to profile the skeletal muscle transcriptome …
understood. We propose an innovative approach to profile the skeletal muscle transcriptome …
[HTML][HTML] The molecular athlete: exercise physiology from mechanisms to medals
Human skeletal muscle demonstrates remarkable plasticity, adapting to numerous external
stimuli including the habitual level of contractile loading. Accordingly, muscle function and …
stimuli including the habitual level of contractile loading. Accordingly, muscle function and …
High-intensity exercise and mitochondrial biogenesis: current controversies and future research directions
It is well established that different types of exercise can provide a powerful stimulus for
mitochondrial biogenesis. However, there are conflicting findings in the literature, and a …
mitochondrial biogenesis. However, there are conflicting findings in the literature, and a …
Human skeletal muscle possesses an epigenetic memory of hypertrophy
It is unknown if adult human skeletal muscle has an epigenetic memory of earlier encounters
with growth. We report, for the first time in humans, genome-wide DNA methylation (850,000 …
with growth. We report, for the first time in humans, genome-wide DNA methylation (850,000 …
[HTML][HTML] DNA methylation in the pathogenesis of type 2 diabetes in humans
Abstract Background Type 2 diabetes (T2D) is a multifactorial, polygenic disease caused by
impaired insulin secretion and insulin resistance. Genome-wide association studies (GWAS) …
impaired insulin secretion and insulin resistance. Genome-wide association studies (GWAS) …
Physical exercise and epigenetic modifications in skeletal muscle
Physical activity and sports play major roles in the overall health status of humans. It is well
known that regular exercise helps to lower the risk for a broad variety of health problems …
known that regular exercise helps to lower the risk for a broad variety of health problems …
[HTML][HTML] Molecular aspects of the exercise response and training adaptation in skeletal muscle
Skeletal muscle plasticity enables an enormous potential to adapt to various internal and
external stimuli and perturbations. Most notably, changes in contractile activity evoke a …
external stimuli and perturbations. Most notably, changes in contractile activity evoke a …
DNA methylation across the genome in aged human skeletal muscle tissue and muscle-derived cells: the role of HOX genes and physical activity
Skeletal muscle tissue demonstrates global hypermethylation with age. However,
methylome changes across the time-course of differentiation in aged human muscle derived …
methylome changes across the time-course of differentiation in aged human muscle derived …