Design space determination and process optimization in at-scale continuous twin screw wet granulation
H Liu, B Ricart, C Stanton, B Smith-Goettler… - Computers & Chemical …, 2019 - Elsevier
At-scale industrial continuous twin screw wet granulation process was analyzed and
optimized via design of experiment (DoE). The Box-Behnken method was selected to …
optimized via design of experiment (DoE). The Box-Behnken method was selected to …
Modelling of urea aggregation efficiency via particle tracking velocimetry in fluidized bed granulation
This work presents a predictive model to estimate the particle size distribution (PSD) and
aggregation efficiency of wet granulation of urea in top spray fluidized bed. To elucidate the …
aggregation efficiency of wet granulation of urea in top spray fluidized bed. To elucidate the …
Assessment of spatial heterogeneity in continuous twin screw wet granulation process using three-compartmental population balance model
In this study, a novel three-compartmental population balance model (PBM) for a continuous
twin screw wet granulation process is developed, combining the techniques of PBM and …
twin screw wet granulation process is developed, combining the techniques of PBM and …
A process optimization strategy of a pulsed-spray fluidized bed granulation process based on predictive three-stage population balance model
H Liu, T O'Connor, S Lee, S Yoon - Powder Technology, 2018 - Elsevier
In this work, a three-stage population balance model (TSPBM) was developed for a pulsed
top-spray fluidized bed granulation (FBG) process. The batch top-spray FBG process was …
top-spray fluidized bed granulation (FBG) process. The batch top-spray FBG process was …
Data-driven adaptive quality control under uncertain conditions for a cyber-pharmaceutical-development system
Z Wang, D He, Y Hou - IEEE Transactions on Industrial …, 2020 - ieeexplore.ieee.org
Pharmaceutical quality control (PQC) holds a critical position in quality by design-based
pharmaceutical development, but development costs are seldom considered due to the …
pharmaceutical development, but development costs are seldom considered due to the …
Optimization of Critical Quality Attributes in Tablet Film Coating and Design Space Determination Using Pilot-Scale Experimental Data
H Liu, R Meyer, M Flamm, L Wareham, M Metzger… - AAPS …, 2021 - Springer
In this study, the novel high-speed tablet film coating process in the continuous
manufacturing was investigated. The influence of key process variables (inlet air flow rate …
manufacturing was investigated. The influence of key process variables (inlet air flow rate …
Data-driven Surrogate Modeling for Computational Fluid Dynamics in Simulating Spray Fluidized Bed Granulation
Z Wang, Y Chen, S Tang, L Yang… - 2023 35th Chinese …, 2023 - ieeexplore.ieee.org
This paper presents a data-driven surrogate modeling methodology for computational fluid
dynamics (CFD) to deliver a more accurate and efficient modeling for simulating segmented …
dynamics (CFD) to deliver a more accurate and efficient modeling for simulating segmented …