Quality control of the mitochondrial proteome
Abstract Mitochondria contain about 1,000–1,500 proteins that fulfil multiple functions.
Mitochondrial proteins originate from two genomes: mitochondrial and nuclear. Hence …
Mitochondrial proteins originate from two genomes: mitochondrial and nuclear. Hence …
Protein quality control at the mitochondrial surface
Mitochondria contain two membranes, the outer and inner membrane. The outer membrane
fulfills crucial functions for the communication of mitochondria with the cellular environment …
fulfills crucial functions for the communication of mitochondria with the cellular environment …
Msp1 clears mistargeted proteins by facilitating their transfer from mitochondria to the ER
S Matsumoto, K Nakatsukasa, C Kakuta, Y Tamura… - Molecular cell, 2019 - cell.com
Normal mitochondrial functions rely on optimized composition of their resident proteins, and
proteins mistargeted to mitochondria need to be efficiently removed. Msp1, an AAA-ATPase …
proteins mistargeted to mitochondria need to be efficiently removed. Msp1, an AAA-ATPase …
A protein quality control pathway at the mitochondrial outer membrane
Maintaining the essential functions of mitochondria requires mechanisms to recognize and
remove misfolded proteins. However, quality control (QC) pathways for misfolded …
remove misfolded proteins. However, quality control (QC) pathways for misfolded …
Cytosolic quality control of mitochondrial protein precursors—the early stages of the organelle biogenesis
AM Lenkiewicz, M Krakowczyk… - International Journal of …, 2021 - mdpi.com
With few exceptions, proteins that constitute the proteome of mitochondria originate outside
of this organelle in precursor forms. Such protein precursors follow dedicated transportation …
of this organelle in precursor forms. Such protein precursors follow dedicated transportation …
Mitochondrial surveillance by Cdc48/p97: MAD vs. membrane fusion
M Escobar-Henriques, V Anton - International Journal of Molecular …, 2020 - mdpi.com
Cdc48/p97 is a ring-shaped, ATP-driven hexameric motor, essential for cellular viability. It
specifically unfolds and extracts ubiquitylated proteins from membranes or protein …
specifically unfolds and extracts ubiquitylated proteins from membranes or protein …
The regulation of mitochondrial homeostasis by the ubiquitin proteasome system
From mitochondrial quality control pathways to the regulation of specific functions, the
Ubiquitin Proteasome System (UPS) could be compared to a Swiss knife without which …
Ubiquitin Proteasome System (UPS) could be compared to a Swiss knife without which …
A AAA ATPase Cdc48 with a cofactor Ubx2 facilitates ubiquitylation of a mitochondrial fusion-promoting factor Fzo1 for proteasomal degradation
S Nahar, A Chowdhury, T Ogura… - The journal of …, 2020 - academic.oup.com
Dynamic functionality of mitochondria is maintained by continual fusion and fission events. A
mitochondrial outer membrane protein Fzo1 plays a pivotal role upon mitochondrial fusion …
mitochondrial outer membrane protein Fzo1 plays a pivotal role upon mitochondrial fusion …
Dual role of a GTPase conformational switch for membrane fusion by mitofusin ubiquitylation
R Schuster, V Anton, T Simões, S Altin… - Life science …, 2020 - life-science-alliance.org
Mitochondria are essential organelles whose function is upheld by their dynamic nature.
This plasticity is mediated by large dynamin-related GTPases, called mitofusins in the case …
This plasticity is mediated by large dynamin-related GTPases, called mitofusins in the case …
[HTML][HTML] Comparative Proteome-Wide Abundance Profiling of Yeast Strains Deleted for Cdc48 Adaptors
The yeast ATPase Cdc48 (known as p97/VCP in human cells) plays an important role in the
Ubiquitin Proteasome System. VCP is essential for cancer cell proliferation, and its …
Ubiquitin Proteasome System. VCP is essential for cancer cell proliferation, and its …