Heme is a ubiquitous and essential iron containing metallo-organic cofactor required for
virtually all aerobic life. Heme synthesis is initiated and completed in mitochondria, followed …

Heme, an iron-containing porphyrin, is of vital importance for cells due to its involvement in
several biological processes, including oxygen transport, energy production and drug …

Mitochondrial fidelity is tightly linked to overall cellular homeostasis and is compromised in
ageing and various pathologies,–. Mitochondrial malfunction needs to be relayed to the …

Protoporphyrin IX (PPIX) is an intermediate in the heme biosynthesis pathway. Abnormal
accumulation of PPIX due to certain pathological conditions such as erythropoietic …

Transition metals are frequently used as cofactors for enzymes and oxygen-carrying proteins
that take advantage of their propensity to gain and lose single electrons. Metals are …

In this contribution we summarize most of the findings reported for the molecular and cellular
biology of the physiological inhibitor of the mitochondrial H+-ATP synthase, the engine of …

Heme is an iron-containing cofactor essential for multiple cellular processes and
fundamental activities such as oxygen transport. To better understand the means by which …

Heme plays a central role in diverse, life-essential processes that range from ubiquitous,
housekee** pathways such as respiration, to highly cell-specific ones such as oxygen …

Cellular oxidative stress results from the increased generation of reactive oxygen species
and/or the dysfunction of the antioxidant systems. Most intracellular reactive oxygen species …

Mitochondrial diseases may result from mutations in the maternally-inherited mitochondrial
DNA (mtDNA) or from mutations in nuclear genes encoding mitochondrial proteins. Their bi …