This comprehensive Review delves into the chemical principles governing RNA-mediated
crowding events, commonly referred to as granules or biological condensates. We explore …

Long noncoding RNA (lncRNA) molecules are some of the newest and least understood
players in gene regulation. Hence, we need good model systems with well-defined RNA and …

A class of long noncoding RNAs (lncRNAs) has architectural functions in nuclear body
construction; however, specific RNA domains dictating their architectural functions remain …

Many membraneless organelles (MLOs) formed through phase separation play crucial roles
in various cellular processes. Although these MLOs co-exist in cells, how they maintain their …

Liver cancer, which is most often associated with virus infection, is prevalent worldwide, and
its underlying etiology and genomic structure are heterogeneous. Here we provide a whole …

Low complexity regions containing biased amino acid composition are abundant in the
proteome, particularly in regulatory molecules, yet the utility and molecular mechanism of …

Approximately half of the world's 500,000 new oesophageal squamous-cell carcinoma
(ESCC) cases each year occur in China. Here, we show whole-genome sequencing of DNA …

Atypical teratoid/rhabdoid tumor (AT/RT) is the most common malignant CNS tumor of
children below 6 months of age. The majority of AT/RTs demonstrate genomic alterations in …

Long intergenic noncoding RNAs (lincRNAs) are long noncoding transcripts (> 200 nt) from
the intergenic regions of annotated protein-coding genes. One of the most highly induced …

Receptor-Interacting Serine/Threonine-Protein Kinase 1 (RIPK1) is a master regulator of
TNFR1 signaling in controlling cell death and survival. While the scaffold of RIPK1 …