ROS1-dependent cancers—biology, diagnostics and therapeutics

A Drilon, C Jenkins, S Iyer, A Schoenfeld… - Nature reviews Clinical …, 2021 - nature.com
The proto-oncogene ROS1 encodes a receptor tyrosine kinase with an unknown
physiological role in humans. Somatic chromosomal fusions involving ROS1 produce …

[HTML][HTML] What do we know about inflammatory myofibroblastic tumors?–a systematic review

K Siemion, J Reszec-Gielazyn, J Kisluk… - Advances in Medical …, 2022 - Elsevier
Abstract Background Inflammatory myofibroblastic tumors (IMTs) are rare intermediate-
grade neoplasms that have a high recurrence rate after excision and exhibit low metastatic …

[HTML][HTML] Best practices recommendations for diagnostic immunohistochemistry in lung cancer

Y Yatabe, S Dacic, AC Borczuk, A Warth… - Journal of thoracic …, 2019 - Elsevier
Since the 2015 WHO classification was introduced into clinical practice,
immunohistochemistry (IHC) has figured prominently in lung cancer diagnosis. In addition to …

Inflammatory myofibroblastic tumour: state of the art

L Gros, AP Dei Tos, RL Jones, A Digklia - Cancers, 2022 - mdpi.com
Simple Summary Among sarcomas, which are rare cancers, inflammatory myofibroblastic
tumors are extremely rare. Unlike other subtypes, this is a largely oncogene-driven …

ALK, ROS1 and NTRK3 gene rearrangements in inflammatory myofibroblastic tumours

H Yamamoto, A Yoshida, K Taguchi, K Kohashi… - …, 2016 - Wiley Online Library
Aims The aim of this study was to elucidate the pathological features of inflammatory
myofibroblastic tumour (IMT) with gene rearrangement other than ALK. Methods and results …

[HTML][HTML] Inflammatory myofibroblastic tumor: the experience of the European pediatric soft tissue sarcoma study group (EpSSG)

M Casanova, B Brennan, R Alaggio, A Kelsey… - European Journal of …, 2020 - Elsevier
Introduction We report the clinical findings and results of treatment in the cohort of patients
with inflammatory myofibroblastic tumor (IMT) managed according to the European pediatric …

[HTML][HTML] Second Paediatric Strategy Forum for anaplastic lymphoma kinase (ALK) inhibition in paediatric malignancies: ACCELERATE in collaboration with the …

ADJ Pearson, E Barry, YP Mossé, F Ligas… - European Journal of …, 2021 - Elsevier
Abstract The first (2017) and sixth (2021) multistakeholder Paediatric Strategy Forums
focused on anaplastic lymphoma kinase (ALK) inhibition in paediatric malignancies. ALK is …

IgG4‐related disease: review of the histopathologic features, differential diagnosis, and therapeutic approach

JR Bledsoe, E Della‐Torre, L Rovati, V Deshpande - Apmis, 2018 - Wiley Online Library
Immunoglobulin G4‐related disease (IgG4‐RD) is an uncommon disorder that demonstrates
characteristic clinicopathologic features including sclerosing lesions with storiform fibrosis …

Inflammatory myofibroblastic tumor: molecular landscape, targeted therapeutics, and remaining challenges

P Mahajan, M Casanova, A Ferrari, A Fordham… - Current Problems in …, 2021 - Elsevier
Inflammatory myofibroblastic tumor (IMT) is a rare mesenchymal tumor of intermediate
malignant potential that predominantly affects children, adolescents and young adults. IMT …

TRK fusion cancers in children: a clinical review and recommendations for screening

CM Albert, JL Davis, N Federman… - Journal of Clinical …, 2019 - ascopubs.org
Chromosomal translocations involving the NTRK1, NTRK2, and NTRK3 genes (TRK
fusions), which encode the neurotrophin tyrosine kinase receptors TRKA, TRKB, and TRKC …