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Advances in biomimetic nanomaterial delivery systems: harnessing nature's inspiration for targeted drug delivery
W Kang, Z Xu, H Lu, S Liu, J Li, C Ding… - Journal of Materials …, 2024 - pubs.rsc.org
The properties of nanomaterials make them promising and advantageous for use in drug
delivery systems, but challenges arise from the immune system's recognition of exogenous …
delivery systems, but challenges arise from the immune system's recognition of exogenous …
Advances in Molecular Research on Hip Joint Im**ement—A Vascular Perspective
With the rise in longevity within the population, medicine continues to encounter fresh
hurdles necessitating prompt actions, among which are those associated with hip joint …
hurdles necessitating prompt actions, among which are those associated with hip joint …
Apoptotic body-inspired nanotherapeutics efficiently attenuate osteoarthritis by targeting BRD4-regulated synovial macrophage polarization
YD Xu, XC Liang, ZP Li, ZS Wu, J Yang, SZ Jia, R Peng… - Biomaterials, 2024 - Elsevier
Abstract Bromodomain-containing protein 4 (BRD4) is the most well-studied BET protein that
is important for the innate immune response. We recently revealed that targeting BRD4 …
is important for the innate immune response. We recently revealed that targeting BRD4 …
GATD3A-deficiency-induced mitochondrial dysfunction facilitates senescence of fibroblast-like synoviocytes and osteoarthritis progression
K Shen, H Zhou, Q Zuo, Y Gu, J Cheng, K Yan… - Nature …, 2024 - nature.com
Accumulating evidence indicates that cellular senescence is closely associated with
osteoarthritis. However, there is limited research on the mechanisms underlying fibroblast …
osteoarthritis. However, there is limited research on the mechanisms underlying fibroblast …
Kongensin A targeting PI3K attenuates inflammation-induced osteoarthritis by modulating macrophage polarization and alleviating inflammatory signaling
Y Guo, P Wang, B Hu, L Wang, Y Zhang… - International …, 2024 - Elsevier
The inflammatory microenvironment, polarization of macrophages towards the M1
phenotype, and consequent matrix degradation and senescence of chondrocytes are …
phenotype, and consequent matrix degradation and senescence of chondrocytes are …
The Hippo signalling pathway in bone homeostasis: Under the regulation of mechanics and aging
The Hippo signalling pathway is a conserved kinase cascade that orchestrates diverse
cellular processes, such as proliferation, apoptosis, lineage commitment and stemness. With …
cellular processes, such as proliferation, apoptosis, lineage commitment and stemness. With …
A Baicalin‐Based Functional Polymer in Dynamic Reversible Networks Alleviates Osteoarthritis by Cellular Interactions
Osteoarthritis (OA) is increasingly recognized as a whole‐organ disease predominantly
affecting the elderly, characterized by typical alterations in subchondral bone and cartilage …
affecting the elderly, characterized by typical alterations in subchondral bone and cartilage …
Metabolic reprogramming of macrophages by a nano-sized opsonization strategy to restore M1/M2 balance for osteoarthritis therapy
R Chen, S Zheng, X Zhao, H Huang, Y Xu, C Qiu… - Journal of Controlled …, 2025 - Elsevier
Osteoarthritis is a chronic and progressive joint disease accompanied by cartilage
degeneration and synovial inflammation. It is associated with an imbalance of synovial …
degeneration and synovial inflammation. It is associated with an imbalance of synovial …
Exploration of the Regulatory Network of Programmed Cell Death Genes in rheumatoid arthritis based on blood-derived circRNA transcriptome information and single …
Y Fang, N Xu, J Shen, H Chen, G Li - Biochemical Genetics, 2024 - Springer
Programmed cell death (PCD) and circular RNA (circRNA) have been found to involve in the
pathogenesis of rheumatoid arthritis (RA). The aim of this study was to explore PCD …
pathogenesis of rheumatoid arthritis (RA). The aim of this study was to explore PCD …
In Situ Dual-targeted Drug Delivery System for Alleviating Imaging and Pathological Damage in Septic Arthritis
Septic arthritis is a severe disease that damages articular cartilage and triggers a strong
inflammatory response. Current treatments mainly depend on systemic antibiotics and lack …
inflammatory response. Current treatments mainly depend on systemic antibiotics and lack …