Synapse dysfunction and loss are hallmarks of neurodegenerative diseases that correlate
with cognitive decline. However, the mechanisms and therapeutic strategies to prevent or …

Determining the causes of schizophrenia has been a notoriously intractable problem,
resistant to a multitude of investigative approaches over centuries. In recent decades …

A genetically valid animal model could transform our understanding of schizophrenia (SCZ)
disease mechanisms. Rare heterozygous loss-of-function (LoF) mutations in GRIN2A …

Background This exploratory study investigated cerebrospinal fluid (CSF) synaptic protein
biomarkers in bipolar disorder (BD), aiming to highlight the neurobiological basis of the …

BackgroundThere is a clear demand for innovative therapeutics for bipolar disorder (BD).
MethodsWe integrated the largest BD genome-wide association study (GWAS) dataset …

The psychosis spectrum encompasses a heterogeneous range of clinical conditions
associated with abnormal brain development. Detecting patterns of atypical …

Recent developments in mass spectrometry-based proteomics have established it as a
robust tool for system-wide analyses essential for pathophysiological research. While post …

Background and aims Multimorbidity, the coexistence of multiple chronic diseases, is a
rapidly expanding global health challenge, carrying profound implications for patients …

Background ClockΔ19 mice demonstrate behavioral characteristics and neurobiological
changes that closely resemble those observed in bipolar disorder (BD). Notably …

Background: Advancement in mental health care requires easily accessible, efficient
diagnostic and treatment assessment tools. Viable biomarkers could enable objectification …