The pathogenesis of Parkinson's disease

HR Morris, MG Spillantini, CM Sue, CH Williams-Gray - The Lancet, 2024 - thelancet.com
Parkinson's disease is a progressive neurodegenerative condition associated with the
deposition of aggregated α-synuclein. Insights into the pathogenesis of Parkinson's disease …

Microbiota–gut–brain axis and its therapeutic applications in neurodegenerative diseases

JS Loh, WQ Mak, LKS Tan, CX Ng, HH Chan… - Signal transduction and …, 2024 - nature.com
The human gastrointestinal tract is populated with a diverse microbial community. The vast
genetic and metabolic potential of the gut microbiome underpins its ubiquity in nearly every …

Inflammation and immune dysfunction in Parkinson disease

MG Tansey, RL Wallings, MC Houser… - Nature Reviews …, 2022 - nature.com
Parkinson disease (PD) is a progressive neurodegenerative disease that affects peripheral
organs as well as the central nervous system and involves a fundamental role of …

Intestinal Akkermansia muciniphila predicts clinical response to PD-1 blockade in patients with advanced non-small-cell lung cancer

L Derosa, B Routy, AM Thomas, V Iebba, G Zalcman… - Nature medicine, 2022 - nature.com
Aside from PD-L1 expression, biomarkers of response to immune checkpoint inhibitors (ICIs)
in non-small-cell lung cancer (NSCLC) are needed. In a previous retrospective analysis, we …

The microbiome–gut–brain axis in Parkinson disease—from basic research to the clinic

AH Tan, SY Lim, AE Lang - Nature Reviews Neurology, 2022 - nature.com
Evidence for a close bidirectional link between the brain and the gut has led to a paradigm
shift in neurology, especially in the case of Parkinson disease (PD), in which gastrointestinal …

Metagenomics of Parkinson's disease implicates the gut microbiome in multiple disease mechanisms

ZD Wallen, A Demirkan, G Twa, G Cohen… - Nature …, 2022 - nature.com
Parkinson's disease (PD) may start in the gut and spread to the brain. To investigate the role
of gut microbiome, we conducted a large-scale study, at high taxonomic resolution, using …

Advancing human gut microbiota research by considering gut transit time

N Procházková, G Falony, LO Dragsted, TR Licht… - Gut, 2023 - gut.bmj.com
Accumulating evidence indicates that gut transit time is a key factor in sha** the gut
microbiota composition and activity, which are linked to human health. Both population-wide …

[HTML][HTML] The role of microbiota-gut-brain axis in neuropsychiatric and neurological disorders

K Socała, U Doboszewska, A Szopa, A Serefko… - Pharmacological …, 2021 - Elsevier
Emerging evidence indicates that the gut microbiota play a crucial role in the bidirectional
communication between the gut and the brain suggesting that the gut microbes may shape …

Signalling cognition: The gut microbiota and hypothalamic-pituitary-adrenal axis

JA Rusch, BT Layden, LR Dugas - Frontiers in endocrinology, 2023 - frontiersin.org
Cognitive function in humans depends on the complex and interplay between multiple body
systems, including the hypothalamic-pituitary-adrenal (HPA) axis. The gut microbiota, which …

Bifidobacterium mechanisms of immune modulation and tolerance

SJ Gavzy, A Kensiski, ZL Lee, EF Mongodin, B Ma… - Gut …, 2023 - Taylor & Francis
Bifidobacterium is a widely distributed commensal bacterial genus that displays beneficial
pro-homeostatic and anti-inflammatory immunomodulatory properties. Depletion or absence …