An update on current therapeutic drugs treating COVID-19

R Wu, L Wang, HCD Kuo, A Shannar, R Peter… - Current pharmacology …, 2020 - Springer
The current pandemic of coronavirus disease 2019 (COVID-19) caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) has presented unprecedented …

[HTML][HTML] Ivermectin: a systematic review from antiviral effects to COVID-19 complementary regimen

F Heidary, R Gharebaghi - The Journal of antibiotics, 2020 - nature.com
Ivermectin proposes many potentials effects to treat a range of diseases, with its
antimicrobial, antiviral, and anti-cancer properties as a wonder drug. It is highly effective …

[HTML][HTML] The FDA-approved drug ivermectin inhibits the replication of SARS-CoV-2 in vitro

L Caly, JD Druce, MG Catton, DA Jans, KM Wagstaff - Antiviral research, 2020 - Elsevier
Although several clinical trials are now underway to test possible therapies, the worldwide
response to the COVID-19 outbreak has been largely limited to monitoring/containment. We …

[HTML][HTML] Effect of ivermectin on time to resolution of symptoms among adults with mild COVID-19: a randomized clinical trial

E López-Medina, P López, IC Hurtado, DM Dávalos… - Jama, 2021 - jamanetwork.com
Importance Ivermectin is widely prescribed as a potential treatment for COVID-19 despite
uncertainty about its clinical benefit. Objective To determine whether ivermectin is an …

The broad spectrum antiviral ivermectin targets the host nuclear transport importin α/β1 heterodimer

SNY Yang, SC Atkinson, C Wang, A Lee… - Antiviral research, 2020 - Elsevier
Infection by RNA viruses such as human immunodeficiency virus (HIV)-1, influenza, and
dengue virus (DENV) represent a major burden for human health worldwide. Although RNA …

The effect of early treatment with ivermectin on viral load, symptoms and humoral response in patients with non-severe COVID-19: A pilot, double-blind, placebo …

C Chaccour, A Casellas, A Blanco-Di Matteo… - …, 2021 - thelancet.com
Background Ivermectin inhibits the replication of SARS-CoV-2 in vitro at concentrations not
readily achievable with currently approved doses. There is limited evidence to support its …

[HTML][HTML] Review of the emerging evidence demonstrating the efficacy of ivermectin in the prophylaxis and treatment of COVID-19

P Kory, GU Meduri, J Varon, J Iglesias… - American journal of …, 2021 - journals.lww.com
Background: After COVID-19 emerged on US shores, providers began reviewing the
emerging basic science, translational, and clinical data to identify potentially effective …

A screen of FDA-approved drugs for inhibitors of Zika virus infection

NJ Barrows, RK Campos, ST Powell, KR Prasanth… - Cell host & …, 2016 - cell.com
Currently there are no approved vaccines or specific therapies to prevent or treat Zika virus
(ZIKV) infection. We interrogated a library of FDA-approved drugs for their ability to block …

Ivermectin–old drug, new tricks?

R Laing, V Gillan, E Devaney - Trends in parasitology, 2017 - cell.com
Ivermectin is one of the most important drugs in veterinary and human medicine for the
control of parasitic infection and was the joint focus of the 2015 Nobel Prize in Physiology or …

[HTML][HTML] Ivermectin and COVID-19: kee** rigor in times of urgency

C Chaccour, F Hammann… - The American journal …, 2020 - ncbi.nlm.nih.gov
Ivermectin is a widely used drug for the treatment and control of several neglected tropical
diseases. 1 The drug has an excellent safety profile, with more than 2.5 billion doses …