Evolution and implications of de novo genes in humans
Genes and translated open reading frames (ORFs) that emerged de novo from previously
non-coding sequences provide species with opportunities for adaptation. When aberrantly …
non-coding sequences provide species with opportunities for adaptation. When aberrantly …
Open questions in the study of de novo genes: what, how and why
The study of de novo protein-coding genes is maturing from the ad hoc reporting of
individual cases to the systematic analysis of extensive genomic data from several species …
individual cases to the systematic analysis of extensive genomic data from several species …
Genomes of 13 domesticated and wild rice relatives highlight genetic conservation, turnover and innovation across the genus Oryza
The genus Oryza is a model system for the study of molecular evolution over time scales
ranging from a few thousand to 15 million years. Using 13 reference genomes spanning the …
ranging from a few thousand to 15 million years. Using 13 reference genomes spanning the …
De novo gene birth
De novo gene birth is the process by which new genes evolve from DNA sequences that
were ancestrally non-genic. De novo genes represent a subset of novel genes, and may be …
were ancestrally non-genic. De novo genes represent a subset of novel genes, and may be …
Genetics on the Fly: A Primer on the Drosophila Model System
Fruit flies of the genus Drosophila have been an attractive and effective genetic model
organism since Thomas Hunt Morgan and colleagues made seminal discoveries with them …
organism since Thomas Hunt Morgan and colleagues made seminal discoveries with them …
Long non-coding RNAs as a source of new peptides
Deep transcriptome sequencing has revealed the existence of many transcripts that lack
long or conserved open reading frames (ORFs) and which have been termed long non …
long or conserved open reading frames (ORFs) and which have been termed long non …
Many, but not all, lineage-specific genes can be explained by homology detection failure
Genes for which homologs can be detected only in a limited group of evolutionarily related
species, called “lineage-specific genes,” are pervasive: Essentially every lineage has them …
species, called “lineage-specific genes,” are pervasive: Essentially every lineage has them …
Synteny-based analyses indicate that sequence divergence is not the main source of orphan genes
The origin of 'orphan'genes, species-specific sequences that lack detectable homologues,
has remained mysterious since the dawn of the genomic era. There are two dominant …
has remained mysterious since the dawn of the genomic era. There are two dominant …
Genes from scratch–the evolutionary fate of de novo genes
C Schlötterer - Trends in Genetics, 2015 - cell.com
Although considered an extremely unlikely event, many genes emerge from previously
noncoding genomic regions. This review covers the entire life cycle of such de novo genes …
noncoding genomic regions. This review covers the entire life cycle of such de novo genes …
Uncovering de novo gene birth in yeast using deep transcriptomics
De novo gene origination has been recently established as an important mechanism for the
formation of new genes. In organisms with a large genome, intergenic and intronic regions …
formation of new genes. In organisms with a large genome, intergenic and intronic regions …